Evidence map›Paper›PMID 33980204›Full record

ArticleBMC cancer2021

Descriptive epidemiology of nasopharyngeal carcinoma at Tikur Anbessa Hospital, Ethiopia.

Elizabeth Tadesse Beyene, Siraw Girum Ketema, Assaye Nibret Alebachew, Mizan Yeshanew Saleh, Tsigereda Atumo Gebremariam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. SEOM-TTCC clinical guideline for nasopharyngeal carcinoma (update 2025).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elizabeth Tadesse BeyeneDepartment of Otorhinolaryngology, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia. estabeth4@yahoo.com.
Siraw Girum KetemaDepartment of Otorhinolaryngology, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
Assaye Nibret AlebachewDepartment of Otorhinolaryngology, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia.
Mizan Yeshanew SalehDepartment of Otorhinolaryngology, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
Tsigereda Atumo GebremariamDepartment of Otorhinolaryngology, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
Addis Ababa University · ETSt. Paul's Hospital Millennium Medical College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNasopharyngeal cancer is distinguished from other cancers of the head and neck in its epidemiology, histopathology, clinical characteristics, and therapeutic outcome. Its unique clinico-epidemiologic pattern of the disease is an area focus for this investigation. Accordingly, the study investigated the demographic and histologic characteristics, as well as the clinical stage at presentation of nasopharyngeal carcinoma patients at Tikur Anbessa Specialized hospital.

methodsHospital based retrospective descriptive study was conducted from September 2017 - October 2020. All biopsy proven incidental cases during the study period are included. SPSS version 26 is used for data entry and analysis.

resultA total of 318 patients with histologically confirmed nasopharyngeal carcinoma cases during the study period were included. There were 218 males and 90 females, with a male: female ratio of 2.5:1. The age of patients ranges from 13 to 81 years with a mean age of 37.8 ± 15 years. The median age at diagnosis was 38 years. Age distribution has two peaks for males, first between 30 to 39 and second 50 to 59 years of age. While the peak age of occurrence for females is in the 20-39 age range. Juvenile cases constituted 34% of the study group. The study revealed, nonkeratinizing carcinoma as the most prevalent histology at 94.3% (undifferentiated type 85.9% and differentiated keratinizing squamous cell carcinoma 8.4%) and 5.7% of the cases showed keratinizing squamous cell carcinoma. Majority of the patients, 86%, presented late with stage III and IV disease.

conclusionNasopharyngeal cancer is commonly found among the young and productive age group, under the age 30. Nonkeratinizing carcinoma is the predominant histopathologic variant resembling that seen in endemic areas of the world. Thus, genetic and early life environmental exposures should be well studied to identify possible risk factors in the region. Late-stage presentation at diagnosis impacts the treatment outcome of patients, thereby indicating the need for a raised index of suspicion among health professionals for early diagnosis and better prognosis of patients.

Indexed as

AdolescentAdultAgedAged, 80 and overAge DistributionEthiopiaFemaleHerpesvirus 4, HumanHumansMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm StagingYoung AdultCarcinomaHistopathologyNasopharyngeal carcinomaNasopharynxTikur Anbessa hospital

Identifiers

PMID33980204
PMCPMC8114688
OpenAlexW3160762165

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.