Evidence map›Paper›PMID 33980158›Full record

ArticleBMC neurology2021

Prevalence and profile of nocturnal disturbances in Chinese patients with advanced-stage Parkinson's disease: a cross-sectional epidemiology study.

Guiying He, Chun-Feng Liu, Qinyong Ye, Zhenguo Liu, Miao Jin, Huifang Shang, Ling Chen, Houzhen Tuo, Hong Jiang, Jifu Cai and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guiying HeDepartment of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chun-Feng LiuThe Second Affiliated Hospital of Soochow University, Suzhou, China.
Qinyong YeFujian Medical University Union Hospital, Fuzhou, China.
Zhenguo LiuXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Miao JinChina-Japan Friendship Hospital, Beijing, China.
Huifang ShangWest China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ling ChenThe First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Houzhen TuoBeijing Friendship Hospital, Capital Medical University, Beijing, China.
Hong JiangXiangya Hospital of Central South University, Changsha, Hunan, China.
Jifu CaiThe University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Kalpesh JoshiGSK, Mumbai, India.
James CooperGSK, Brentford, Middlesex, UK.
Lu ZiGSK, Shanghai, China.
Shengdi ChenDepartment of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. chensd@rjh.com.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of nocturnal disturbance (ND) in Parkinson's disease on quality of life of patients in Western Countries is increasingly understood. Our study aimed to investigate ND prevalence and its quality of life impact in patients with advanced Parkinson's disease in China.

methodsIn a multicenter, tertiary-care hospital, outpatient-based, cross-sectional study, patients with advanced Parkinson's disease (Modified Hoehn & Yahr [H&Y] Stage II-IV with ≥3 h awake "off" time/day) from 10 tertiary hospitals throughout China completed the Parkinson's Disease Sleep Scale-2 (PDSS-2) and Parkinson's Disease Questionnaire-39 (PDQ-39). The primary endpoint was the percentage of patients with significant ND (PDSS-2 total score ≥ 15). Additional endpoints were demographic and clinical characteristics, PDSS-2 and PDQ-39 total and subscale scores, correlation between PDSS-2 and PDQ-39, and risk factors for ND and higher PDSS-2 or PDQ-39 scores.

resultsOf 448 patients analyzed (mean age 63.5 years, 47.3% female), 70.92% (95% confidence interval: 66.71, 75.13) had significant ND. Presence of ND and higher PDSS-2 scores were associated with longer disease duration and higher H&Y stage. Presence of ND was also associated with more awake "off" time/day and female sex. PDQ-39 scores were significantly worse for patients with ND versus those without ND; worse scores were associated with more awake "off" time/day, female sex, and higher H&Y stage. PDSS-2 and PDQ-39 total scores were associated: Pearson correlation coefficient 0.62 (p < 0.001).

conclusionsIn China, ND was highly prevalent in patients with advanced Parkinson's disease and adversely impacted quality of life. This study highlights the importance of early diagnosis and optimized management of ND in patients with Parkinson's disease in China.

Indexed as

Quality of LifeAgedAsian PeopleChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedParkinson DiseasePrevalenceSleepSleep Wake DisordersSurveys and QuestionnairesChinaNocturnal disturbancesParkinson’s diseasePrevalenceQuality of lifeSleep disorders

Identifiers

PMID33980158
PMCPMC8114718

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.