Evidence map›Paper›PMID 33979992›Full record

ArticleHaematologica2021

Low incidence of COVID-19 severe complications in a large cohort of children with sickle cell disease: a protective role for basal interferon-1 activation?

Valentine Brousse, Laurent Holvoet, Rémi Pescarmona, Sebastien Viel, Magali Perret, Benoit Visseaux, Valentine Marie Ferre, Ghislaine Ithier, Caroline Le Van Kim, Malika Benkerrou and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07753772 (Perioperative Use of Dexmedetomidine-esketamine Combination on Depression and Anxiety in Patients Undergoing Laparoscopic Ureteral Reconstruction), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07753772 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Perioperative Use of Dexmedetomidine-esketamine Combination on Depression and Anxiety in Patients Undergoing Laparoscopic Ureteral Reconstruction: a Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2029Enrolled658ConditionsUreteral Stricture, Dexmedetomidine, Esketamine, Depressive SymptomsArmsCombined dexmedetomidine-esketamine administration, Placebo administration
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Valentine BrousseSickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris, France; Université de Paris, UMR_S1134, BIGR, INSERM, Institut National de la Transfusion Sanguine, Laboratoire d'Excellence GR-Ex, F-75015 Paris.
Laurent HolvoetSickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris.
Rémi PescarmonaCIRI, Centre International de Recherche en Infectiologie, Université Lyon 1, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS, F-69100 Lyon, France; Laboratoire d'Immunologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F- 69310 Pierre-Bénite.
Sebastien VielCIRI, Centre International de Recherche en Infectiologie, Université Lyon 1, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS, F-69100 Lyon, France; Laboratoire d'Immunologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F- 69310 Pierre-Bénite.
Magali PerretCIRI, Centre International de Recherche en Infectiologie, Université Lyon 1, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS, F-69100 Lyon, France; Laboratoire d'Immunologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F- 69310 Pierre-Bénite.
Benoit VisseauxUniversité de Paris, Assistance Publique - Hôpitaux de Paris, Service de virologie, Hôpital Bichat; INSERM UMR 1137-IAME, DeSCID: Decision SCiences in Infectious Diseases control and care, F-75018 Paris.
Valentine Marie FerreUniversité de Paris, Assistance Publique - Hôpitaux de Paris, Service de virologie, Hôpital Bichat; INSERM UMR 1137-IAME, DeSCID: Decision SCiences in Infectious Diseases control and care, F-75018 Paris.
Ghislaine IthierSickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris.
Caroline Le Van KimUniversité de Paris, UMR_S1134, BIGR, INSERM, Institut National de la Transfusion Sanguine, Laboratoire d'Excellence GR-Ex, F-75015 Paris.
Malika BenkerrouSickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris, France; Université de Paris, INSERM UMR 1123, ECEVE, F-75010 Paris.
Florence MissudSickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris.
Berengere KoehlSickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Assistance Publique - Hôpitaux de Paris, F-75019 Paris, France; Université de Paris, UMR_S1134, BIGR, INSERM, Institut National de la Transfusion Sanguine, Laboratoire d'Excellence GR-Ex, F-75015 Paris. berengere.koehl@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellCOVID-19ChildHumansIncidenceInterferonsSARS-CoV-2Interferons

Identifiers

PMID33979992
PMCPMC8485686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.