Evidence map›Paper›PMID 33979955›Full record

ArticleZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2021

[Research progress of serum biomarkers for early screening of hepatocellular carcinoma].

W Zhu, Y Huang

Abstract read
In one paragraph

Article in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

W ZhuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China.
Y HuangDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China.

Funding

National Key R&D Program of China 2017YFC0908104" Thirteenth Five-Year Plan" National Science and Technology Major Project of China 2018ZX10732-202-001
6 · The paper itself

Abstract

The latest research data shows that the cause of death of liver cancer patients ranks third among malignant tumors. The global situation of early detection, early diagnosis and early treatment of liver cancer is severe. Therefore, how to achieve early diagnosis of liver cancer has important clinical significance. At present, alpha-fetoprotein, alpha-fetoprotein-L3 and des-gamma-carboxythrombin are commonly used in the clinical detection of hepatocellular carcinoma; however, their sensitivity cannot meet the diagnostic needs of patients with early liver cancer. With the development of molecular biology techniques such as serum oligosaccharide chains detection, B10, a member of the aldehyde ketone reductase family, microRNAs, circulating tumor cells, DNA methylation, and other novel serum biomarkers, a new option for the early screening and diagnosis of hepatocellular carcinoma patients will be offered.

Indexed as

Carcinoma, HepatocellularLiver Neoplasmsalpha-FetoproteinsBiomarkersBiomarkers, TumorEarly Detection of CancerHumansProtein PrecursorsProthrombinalpha-FetoproteinsBiomarkersBiomarkers, TumorProtein PrecursorsProthrombinEarly diagnosisHepatocellular carcinaomaSerum biomarker

Identifiers

PMID33979955
PMCPMC12814038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.