Evidence map›Paper›PMID 33979633›Full record

ArticleNeuron2021

Visual intracortical and transthalamic pathways carry distinct information to cortical areas.

Antonin Blot, Morgane M Roth, Ioana Gasler, Mitra Javadzadeh, Fabia Imhof, Sonja B Hofer

Abstract read
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Modulation and Gating of Transthalamic and Subcortical Pathways through Somatosensory Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  6. Article
  7. Individual Pulvinar Neurons Integrate Cortical and Subcortical Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Complementary Organization of Mouse Driver and Modulator Cortico-thalamo-cortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Article
  15. Transthalamic Pathways for Cortical Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Antonin BlotSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK; Biozentrum, University of Basel, Basel, Switzerland.
Morgane M RothBiozentrum, University of Basel, Basel, Switzerland.
Ioana GaslerSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK; Biozentrum, University of Basel, Basel, Switzerland.
Mitra JavadzadehSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK; Biozentrum, University of Basel, Basel, Switzerland.
Fabia ImhofBiozentrum, University of Basel, Basel, Switzerland.
Sonja B HoferSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK; Biozentrum, University of Basel, Basel, Switzerland. Electronic address: s.hofer@ucl.ac.uk.

Funding

Wellcome TrustWellcome Trust 090843/F/09/Z
6 · The paper itself

Abstract

Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual system of rodents. The fine-scale organization and function of these cortico-thalamo-cortical pathways remains unclear. We find that responses of mouse LP neurons projecting to higher visual areas likely derive from feedforward input from primary visual cortex (V1) combined with information from many cortical and subcortical areas, including superior colliculus. Signals from LP projections to different higher visual areas are tuned to specific features of visual stimuli and their locomotor context, distinct from the signals carried by direct intracortical projections from V1. Thus, visual transthalamic pathways are functionally specific to their cortical target, different from feedforward cortical pathways, and combine information from multiple brain regions, linking sensory signals with behavioral context.

Indexed as

AnimalsCerebral CortexLateral Thalamic NucleiLocomotionMiceNeuronsPhotic StimulationPulvinarSuperior ColliculiThalamusVisual CortexVisual Pathwayshigher visual areaspulvinarthalamocortical interactionsthalamusvisionvisual cortexvisual processing

Identifiers

PMID33979633
PMCPMC8221812

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.