Evidence map›Paper›PMID 33979214›Full record

ArticleAmerican journal of physiology. Cell physiology2021

Mechanics of dystrophin deficient skeletal muscles in very young mice and effects of age.

Michael A Lopez, Sherina Bontiff, Mary Adeyeye, Aziz I Shaibani, Matthew S Alexander, Shari Wynd, Aladin M Boriek

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. AAVcc47-The Yale journal of biology and medicine · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Dystrophin missense mutations alter focal adhesion tension and mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael A LopezDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Sherina BontiffDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Mary AdeyeyeDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Aziz I ShaibaniDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Matthew S AlexanderDepartment of Pediatrics, University of Alabama Birmingham, Birmingham, Alabama.
Shari WyndDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Aladin M BoriekDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Baylor College of Medicine · USUniversity of Alabama at Birmingham · US

Funding

UAB Pilot Center for Precision Animal Modeling (C-PAM) - Resource and Service SectionU54OD030167 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Bradley K. Yoder · 2020 to 2026
$15.3M
PHYSIOLOGY OF RESPIRATORY MUSCLE MIRCO MECHANICSR01HL063134 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BORIEK, ALADIN M · 2001 to 2009
$3.0M
A MIR-486/DOCK3 SIGNALING AXIS MODULATES DYSTROPHIN-DEFICIENT PATHOLOGYR01HD095897 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALEXANDER, MATTHEW SCOTT · 2018 to 2022
$1.6M
Smad8 is a driver of Duchenne muscular dystrophy pathology via myomiR repressionK08NS120812 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOPEZ, MICHAEL ALONZO · 2021 to 2025
$1.1M
Micro RNAs as biomarkers and therapeutic targets in myotubular myopathyR21AR074006 · NIAMS · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI ALEXANDER, MATTHEW SCOTT, DOWLING, JAMES J · 2018 to 2019
$337k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL-63134NHLBI NIH HHS R01 HL063134NIAMS NIH HHS R21 AR074006NICHD NIH HHS R01 HD095897NIH HHS U54 OD030167NINDS NIH HHS K08 NS120812
6 · The paper itself

Abstract

The MDX mouse is an animal model of Duchenne muscular dystrophy, a human disease marked by an absence of the cytoskeletal protein, dystrophin. We hypothesized that

Indexed as

AnimalsDisease Models, AnimalDystrophinIsometric ContractionMice, TransgenicMuscle ContractionMuscle Fibers, SkeletalMuscle, SkeletalMuscular Dystrophy, DuchenneDystrophinMDX muscle pathologymuscle weaknessrespiratory muscle mechanics

Identifiers

PMID33979214
PMCPMC8424675
OpenAlexW3160808967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.