ArticleBiomedical chromatography : BMC2021
Pharmacokinetic study of an anti-trypanosome agent with different formulations and administration routes in mice by HPLC-MS/MS.
Yaxin Li, Cody M Orahoske, Raina Dano, Wenjing Zhang, Bibo Li, Bin Su
Abstract read
In one paragraphArticle in Biomedical chromatography : BMC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Yaxin LiDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Cody M OrahoskeDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Raina DanoDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Wenjing ZhangDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Bibo LiDepartment of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Bin SuDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-0711-441X Funding
Selective tubulin inhibitors with improved cell update for kinetoplastid infectionsR15AI103889 · NIAID · CLEVELAND STATE UNIVERSITY · PI SU, BIN · 2013 to 2016
$873kA Digital Laser Scanner Biomolecular Imaging System: Amersham Typhoon 5S10OD025252 · OD · CLEVELAND STATE UNIVERSITY · PI LI, BIBO · 2018 to 2018
$163kNational Institute of Allergy and Infectious Diseases R15AI 103889National Science Foundation CHE-0923398National Science Foundation CHE-1126384NIAID NIH HHS R15 AI103889NIH HHS S10 OD025252
6 · The paper itselfAbstract
Previously compound 12 showed great anti-trypanosome activity without toxicity in an in vivo study. In the current study, a sensitive and rapid high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated to investigate its pharmacokinetics in mouse plasma. A protein precipitation method was applied to extract the compound, and it was then separated using a Kinetex C
Indexed as
Trypanocidal AgentsAdministration, OralAnimalsChromatography, High Pressure LiquidGlycerolInjections, IntraperitonealLinear ModelsMaleMiceReproducibility of ResultsSensitivity and SpecificitySesame OilTandem Mass Spectrometrycremophor ELGlycerolSesame OilTrypanocidal Agentsanti-trypanosomeCremophor ELHPLC-MS/MSpharmacokineticssesame oil
Identifiers
PMID33978959
PMCPMC8434948
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