Evidence map›Paper›PMID 33978924›Full record

Trial reportAging clinical and experimental research2021

Evaluation of the efficacy of physical therapy on cognitive decline at 6-month follow-up in Parkinson disease patients with mild cognitive impairment: a randomized controlled trial.

Micol Avenali, Marta Picascia, Cristina Tassorelli, Elena Sinforiani, Sara Bernini

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04012086 nacompletednot on this map

Intensive Physical Therapy Mitigates Cognitive Decline in People With Parkinson's Disease

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2015 to 2018Enrolled40ConditionsParkinson Disease, Cognitive ImpairmentArmsPhysical therapy
NCT07618728 narecruitingnot on this mapstarted 2025, after this paper: background citation

Feasibility and Preliminary Effectiveness of an Individualised Multimodal Group-Based Exercise Programme for People With Parkinson's Disease: A Non-Randomized Feasibility Study

TypeinterventionalSponsorUniversidad Rey Juan CarlosRan2025 to 2027Enrolled64ConditionsPARKINSON DISEASE (Disorder)ArmsExercise Group
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Micol AvenaliDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0002-7880-9921
Marta PicasciaIRCCS Mondino Foundation, Via Mondino 2, 20100, Pavia, Italy.ORCID http://orcid.org/0000-0001-6774-0159
Cristina TassorelliDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0003-1513-2113
Elena SinforianiIRCCS Mondino Foundation, Via Mondino 2, 20100, Pavia, Italy.ORCID http://orcid.org/0000-0001-5512-6936
Sara BerniniIRCCS Mondino Foundation, Via Mondino 2, 20100, Pavia, Italy. sara.bernini@mondino.it.ORCID http://orcid.org/0000-0001-8615-0242
University of Pavia · ITFoundation Center · US

Funding

Ministero della Salute Ricerca Corrente 2017-2019
6 · The paper itself

Abstract

backgroundIn Parkinson's disease (PD), physical activity may represent a possible non-pharmacological intervention not only for improving motor symptoms but also for modulating cognitive impairment.

aimsTo evaluate the efficacy of an intensive physical program on cognitive functions in mid-stage PD patients with mild cognitive impairment (PD-MCI) over a 6-month follow-up.

methodsThis is a 6-month randomized controlled follow-up study. 40 PD-MCI patients were randomized to receive physical therapy (PT) or no specific intervention beside drug treatment (CT). Cognitive and motor assessments were performed at baseline (T0), 4 weeks after baseline (T1) and 6 months after T0. In a previous study, we reported a significant improvement in global cognitive functioning and attention/working-memory at T1. Here, we evaluated the residual effect of the training intervention at 6 months on both cognitive and motor performances.

resultsIntra-group analysis showed that at T2 most of cognitive and motor performances remained stable in the PT when compared to T0, while a significant worsening was observed in the CT. Between-group comparison at T2 showed significantly better results in PT than CT as regards MoCA and motor scales. The percentage change of cognitive and motor performances between T1 and T2 confirmed the benefit of physical therapy on global cognitive functioning scores (MMSE and MoCA).

conclusionsIn this follow-up extension of a longitudinal randomized controlled study, we demonstrated that physical therapy has a positive effect on cognitive functions, which extends beyond the duration of the treatment itself to, at least temporarily, reducing cognitive decline.

trial registrationTrial registration number (ClinicalTrials.gov): NCT04012086 (9th July 2019).

Indexed as

Cognitive DysfunctionParkinson DiseaseCognitionFollow-Up StudiesHumansPhysical Therapy ModalitiesMild cognitive impairmentNon-pharmacological interventionsParkinson’s diseasePhysical therapy

Identifiers

PMID33978924
OpenAlexW3162305381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.