Evidence map›Paper›PMID 33978902›Full record

ArticleMetabolic brain disease2021

Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP

Adaze Bijou Enogieru, William Haylett, Donavon Hiss, Okobi Ekpo

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frontiers in pharmacology · 2023
    Review
  5. Protective Application ofAnimals : an open access journal from MDPI · 2022
    Review
  6. Article
  7. HimalayanPlants (Basel, Switzerland) · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Adaze Bijou EnogieruDepartment of Medical Biosciences, University of the Western Cape, Robert Sobukwe Road, Private Bag X17, Bellville, 7535, South Africa. 3581698@myuwc.ac.za.ORCID 0000-0001-8262-5220
William HaylettDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Donavon HissDepartment of Medical Biosciences, University of the Western Cape, Robert Sobukwe Road, Private Bag X17, Bellville, 7535, South Africa.
Okobi EkpoDepartment of Medical Biosciences, University of the Western Cape, Robert Sobukwe Road, Private Bag X17, Bellville, 7535, South Africa. okobi.ekpo@ku.ac.ae.
Khalifa University of Science and Technology · AEStellenbosch University · ZAUniversity of Benin · NGUniversity of the Western Cape · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many plant-derived bioactive compounds such as rutin are reportedly effective in attenuating neuronal death in most neurodegenerative disorders. Parkinson's disease (PD) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra of the midbrain, and has previously been modelled in-vitro through the specific neurotoxic activity of 1-methyl-4-phenylpyridinium (MPP

Indexed as

Neurodegenerative DiseasesNeuroprotective Agents1-Methyl-4-phenylpyridiniumAntioxidantsApoptosisCell Line, TumorCell SurvivalCyclooxygenase 2Dopaminergic NeuronsHumansReactive Oxygen SpeciesRutin1-Methyl-4-phenylpyridiniumAntioxidantsCyclooxygenase 2Neuroprotective AgentsReactive Oxygen SpeciesRutinCOX-2Nitric oxideParkinson’s diseaseReactive oxygen speciesRutinΓH2AX

Identifiers

PMID33978902
OpenAlexW3162375804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.