Evidence map›Paper›PMID 33978862›Full record

ArticleCellular and molecular neurobiology2021

Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak.

Kelly M Standifer, Charles E Inturrisi, Kathleen M Foley, Ying-Xian Pan

Open access · greenAbstract readBiographyEditorialHistorical Article
In one paragraph

Article in Cellular and molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Kelly M StandiferDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Kelly-standifer@ouhsc.edu.ORCID http://orcid.org/0000-0002-3246-8703
Charles E InturrisiDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0890-6275
Kathleen M FoleyMemorial Sloan Kettering Cancer Center Member Emeritus, New York, NY, USA.ORCID http://orcid.org/0000-0001-9707-007X
Ying-Xian PanDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, NY, USA.ORCID http://orcid.org/0000-0002-4006-8304
Cornell University · USMemorial Sloan Kettering Cancer Center · USOklahoma City University · USRutgers, The State University of New Jersey · US

Funding

TRAINING IN BEHAV. PHARMACOLOGY OF HUMAN DRUG DEPENDENCET32DA007242 · NIDA · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI HEIL, SARAH H, HIGGINS, STEPHEN T · 1990 to 2025
$8.2M
PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPESR01DA007242 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAN, YING-XIAN · 1991 to 2022
$6.0M
Alternative pre-mRNA splicing of mu opioid receptor gene and mu opioid actionsR01DA042888 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2017 to 2021
$1.9M
PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPESR37DA007242 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PASTERNAK, GAVRIL W · 1996 to 2004
$1.5M
Mapping mu agonist-induced receptor-protein interactions for OPRM1 7TM variantsR21DA046714 · NIDA · SLOAN-KETTERING INST CAN RESEARCH · PI PAN, YING-XIAN · 2018 to 2019
$502k
NIDA NIH HHS DA042888NIDA NIH HHS DA046714NIDA NIH HHS DA07242NIDA NIH HHS R01 DA007242NIDA NIH HHS R37 DA007242NIDA NIH HHS T32 DA007242
6 · The paper itself

Abstract

This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD, PhD. Homage to the breadth and depth of his work (~ 450 publications) over a 40 career in pharmacology and medicine cannot be captured fully in one special issue, but the 22 papers collected herein represent seven of the topics near and dear to Gav's heart, and the colleagues, friends and mentees who held him near to theirs. The seven themes include: (1) sites and mechanisms of opioid actions in vivo; (2) development of novel analgesic agents; (3) opioid tolerance, withdrawal and addiction: mechanisms and treatment; (4) opioid receptor splice variants; (5) novel research tools and approaches; (6) receptor signaling and crosstalk in vitro; and (7) mentorship. This introduction to the issue summarizes contributions and includes formal and personal remembrances of Gav that illustrate his personality, warmth, and dedication to making a difference in patient care and people's lives.

Indexed as

AnalgesiaAnalgesics, OpioidHistory, 20th CenturyHistory, 21st CenturyHumansLaboratory PersonnelPainPain ManagementPhysiciansReceptors, OpioidAnalgesics, OpioidReceptors, OpioidAnalgesiaKratom alkaloidsNociception/orphanin FQOpioid receptorsOpioid tolerance and withdrawalSplice variants

Identifiers

PMID33978862
PMCPMC11448670
OpenAlexW3160159674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.