Evidence map›Paper›PMID 33978829›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation.

Meike Dirks, Ralph Buchert, Ann-Katrin Wirries, Henning Pflugrad, Gerrit M Grosse, Carlotta Petrusch, Christian Schütze, Florian Wilke, Martin Mamach, Linda Hamann and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  3. Article
  4. Imaging translocator protein expression with positron emission tomography.European journal of nuclear medicine and molecular imaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 1 country.

Meike DirksDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. dirks.meike@mh-hannover.de.ORCID http://orcid.org/0000-0002-9661-7704
Ralph BuchertDepartment of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ann-Katrin WirriesDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Henning PflugradDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Gerrit M GrosseDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Carlotta PetruschDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Christian SchützeDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Florian WilkeDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Martin MamachDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Linda HamannDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Laura B N LangerDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Xiao-Qi DingInstitute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.
Hannelore Barg-HockGeneral, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
Jürgen KlempnauerGeneral, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
Christian H WetzelDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Mario LukacevicDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Eike JanssenDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Mariella KesslerDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Frank M BengelDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Lilli GeworskiDepartment of Medical Physics and Radiation Protection, Hannover Medical School, Hannover, Germany.
Rainer RupprechtDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Tobias L RossDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Georg Berding *Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Karin Weissenborn *Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Medizinische Hochschule Hannover · DEUniversity of Regensburg · DEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCalcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) imaging with the translocator protein (TSPO) ligand

methodsPET was performed in 22 liver-transplanted patients (3 CNI free, 9 with low-dose CNI, 10 with standard-dose CNI immunosuppression) and 9 healthy controls. The total distribution volume (V

resultsIn controls, V

conclusionOur results provide evidence of chronic suppression of microglial activity in liver-transplanted patients under CNI therapy especially in patients with high sensitivity to CNI toxicity.

Indexed as

Liver TransplantationMicrogliaBrainHumansImmunosuppression TherapyPositron-Emission TomographyReceptors, GABAReceptors, GABATSPO protein, human18F-GE-180Cognitive functionImagingImmunosuppressionTranslocator protein (TSPO)

Identifiers

PMID33978829
PMCPMC8712291
OpenAlexW3162349213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.