ArticleeLife2021
Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- A cryptic symmetry switch allosterically controls how the PF4 self-protein turns into a pathogenic antigen.Nature communications · 2026Article
- Energy Landscape Analysis of Membrane Proteins Using NMR-Based Hybrid Restraint Potentials.Journal of chemical theory and computation · 2026Article
- Effects of low-dose lithium supplementation on thermal inactivation of SERCA in cardiac muscle of male mice.Bioscience reports · 2026Article
- Integrating NMR Restraints into Coarse-Grained Simulations: Toward Accurate Conformational Ensembles of Complex Protein Systems.Journal of the American Chemical Society · 2026Article
- Disrupted SR-Mitochondria Coupling Drives Ischemia-Reperfusion Vulnerability in the Middle-Aged Rat Heart.Biomedicines · 2026Article
- Article
- The SERCA-PLN-DWORF axis in cardiometabolic disease: mechanisms and therapeutic perspectives.Cardiovascular diabetology · 2025Review
- Allosteric Modulation of SERCA Pumps in Health and Disease: Structural Dynamics, Posttranslational Modifications, and Therapeutic Potential.Journal of molecular biology · 2025Review
- Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Calcium-dependent levels of phospholamban pentamer in native heart membranes reflect interactions of monomers with calcium-free SERCA2a.Archives of biochemistry and biophysics · 2025Article
- Environment-induced heat stress causes ventricular-dependent biochemical changes in the heart in female pigs.Physiological reports · 2025Article
- SERCA2a dysfunction in the pathophysiology of heart failure with preserved ejection fraction: a direct role is yet to be established.Heart failure reviews · 2025Review
- Redox Regulation of cAMP-Dependent Protein Kinase and Its Role in Health and Disease.Life (Basel, Switzerland) · 2025Review
- The role of A-kinase anchoring proteins in cardiovascular diseases and recent advances.Frontiers in cell and developmental biology · 2025Review
- Genetic landscape of phospholamban cardiomyopathies.Frontiers in cell and developmental biology · 2025Review
- Far-infrared irradiation attenuates vessel contraction by activating SERCA2 through disruption of SERCA2 and PLN interaction.PloS one · 2025Article
- β-adrenergic regulation of CaBiophysics reports · 2024Article
- Pathological mutations in the phospholamban cytoplasmic region affect its topology and dynamics modulating the extent of SERCA inhibition.Biochimica et biophysica acta. Biomembranes · 2024Article
- Article
- SERCA2 phosphorylation at serine 663 is a key regulator of CaNature communications · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Daniel K WeberDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.ORCID 0000-0001-8400-767X
U Venkateswara ReddyDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.
Songlin WangDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.ORCID 0000-0002-7588-7377
Erik K LarsenDepartment of Chemistry, University of Minnesota, Minneapolis, United States.ORCID 0000-0002-7553-212X
Tata GopinathDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.
Martin B GustavssonDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.
Razvan L CorneaDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.
David D ThomasDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.ORCID 0000-0002-8822-2040
Alfonso De SimoneDepartment of Life Sciences, Imperial College London, South Kensington, London, United Kingdom.ORCID 0000-0001-8789-9546
Gianluigi VegliaDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, United States.ORCID 0000-0002-2795-6964
University of Minnesota · USImperial College London · GB
Funding
NMR Structural Analysis of Calcium Regulation in MuscleR01GM064742 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VEGLIA, GIANLUIGI · 2002 to 2019
$7.1MStructural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2MSite-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5MProtein Oxidation, Structure, &Function in Aging MuscleR01AG026160 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 2004 to 2008
$2.2MStructural Basis of Dilated CardiomyopathyR01HL144130 · NHLBI · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2018 to 2021
$1.5MNHLBI NIH HHS R01 HL139065NHLBI NIH HHS R01 HL144130NIA NIH HHS R01 AG026160NIA NIH HHS R37 AG026160NIGMS NIH HHS R01 GM064742
Abstract
Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca
Indexed as
Allosteric RegulationPhosphorylationAnimalsCalciumCalcium-Binding ProteinsEscherichia coliMagnetic Resonance SpectroscopyMembrane ProteinsMolecular StructurePhospholambanProtein ConformationRabbitsSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSignal TransductionCalciumCalcium-Binding ProteinsMembrane ProteinsPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasesE. colimembrane proteinsmolecular biophysicsoriented solidstate NMRstructural biologytopological allostery
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.