Evidence map›Paper›PMID 33978570›Full record

ArticleeLife2021

NHR-49/PPAR-α and HLH-30/TFEB cooperate for

Khursheed A Wani, Debanjan Goswamy, Stefan Taubert, Ramesh Ratnappan, Arjumand Ghazi, Javier E Irazoqui

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Phenotypic and metabonomics studies of FMOs in C. elegans and their roles in lifespan extension.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Flavin-containing monooxygenase (FMO): Beyond xenobiotics.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. ThemBio · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Khursheed A WaniDepartment of Microbiology and Physiological Systems, UMass Medical School, Worcester, United States.ORCID 0000-0003-3559-7962
Debanjan GoswamyDepartment of Microbiology and Physiological Systems, UMass Medical School, Worcester, United States.
Stefan TaubertDepartment of Medical Genetics, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-2432-7257
Ramesh RatnappanDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID 0000-0001-7055-9043
Arjumand GhaziDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID 0000-0002-5859-4206
Javier E IrazoquiDepartment of Microbiology and Physiological Systems, UMass Medical School, Worcester, United States.ORCID 0000-0001-6553-1329
University of Massachusetts Chan Medical School · USUniversity of Pittsburgh · USUniversity of British Columbia · CA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Role of MiT Transcription Factors in Host Defense Against Bacterial InfectionR01GM101056 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IRAZOQUI, JAVIER ELBIO · 2012 to 2022
$3.9M
The Coordination of Lipid Synthesis and Breakdown in Metabolism and AgingR01AG051659 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GHAZI, ARJUMAND · 2016 to 2019
$1.6M
CIHR PJT-153199NIA NIH HHS R01 AG051659NIGMS NIH HHS R01 GM101056NIH HHS P40 OD010440
6 · The paper itself

Abstract

The model organism

Indexed as

Immunity, InnateAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsFood DeprivationOxygenasesPPAR alphaReceptors, Cytoplasmic and NuclearStaphylococcal InfectionsStaphylococcus aureusBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans Proteinsdimethylaniline monooxygenase (N-oxide forming)HLH-30 protein, C elegansNHR-49 protein, C elegansOxygenasesPPAR alphaReceptors, Cytoplasmic and NuclearC. eleganshost defenseimmunologyinflammationintestineS. aureustranscription factors

Identifiers

PMID33978570
PMCPMC8139828
OpenAlexW3096562070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.