Evidence map›Paper›PMID 33978490›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Sympathetic activation due to limb venous distension is preserved during muscle metaboreceptor stimulation.

Jian Cui, Cheryl Blaha, Urs A Leuenberger, Lawrence I Sinoway

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. The effects of limb suction during arterial occlusion on arterial baroreflex in humans.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  3. Review
  4. Article
  5. Frontiers in physiology · 2023
    Article
  6. Baroreflex responses to limb venous distension in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jian CuiPenn State Hershey Heart and Vascular Institute, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Cheryl BlahaPenn State Hershey Heart and Vascular Institute, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Urs A LeuenbergerPenn State Hershey Heart and Vascular Institute, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Lawrence I SinowayPenn State Hershey Heart and Vascular Institute, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
The Human Cardiovascular Control: The Role of Limb VeinsR01HL144781 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CUI, JIAN, SINOWAY, LAWRENCE I · 2019 to 2023
$2.7M
NCATS NIH HHS UL1 TR002014NHLBI NIH HHS R01 HL144781
6 · The paper itself

Abstract

Venous saline infusions in an arterially occluded forearm evoke reflex increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP) in humans (venous distension reflex). It is unclear if the inputs from metabolically sensitive skeletal muscle afferents (i.e., muscle metaboreflex) would modify the venous distension reflex. We hypothesized that muscle metaboreceptor stimulation might augment the venous distension reflex. BP (Finapres), heart rate (ECG), and MSNA (microneurography) were assessed in 18 young healthy subjects. In

Indexed as

AdultFemaleForearmHumansHyperemiaMaleMuscle, SkeletalReflexSympathetic Nervous SystemVenous Pressureautonomicblood pressure controlexercisesympatheticvein

Identifiers

PMID33978490
PMCPMC8321786
OpenAlexW3161189531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.