Evidence map›Paper›PMID 33978165›Full record

ArticleThe Journal of nutrition2021

Calcium Intake Is Inversely Related to Risk of Obesity among American Young Adults over a 30-Year Follow-Up.

Liping Lu, Cheng Chen, Jie Zhu, Wenjing Tang, David R Jacobs, James M Shikany, Ka Kahe

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Liping LuDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Cheng ChenDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jie ZhuNutrition and Foods Program, School of Family and Consumer Sciences, Texas State University, San Marcos, TX, USA.
Wenjing TangDepartment of Clinical Nutrition, Xin Hua Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-7232-0543
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ka KaheDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Columbia University · USShanghai Jiao Tong University · CNTexas State University · USUniversity of Alabama at Birmingham · USUniversity of Minnesota · US

Funding

Trace mineral levels, metabolomics, and diabetes riskR01DK116603 · NIDDK · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2018 to 2019
$1.5M
Trace Elements and CVD Risks Factors Among Young AdultsR01HL081572 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAHE, KA · 2006 to 2008
$1.2M
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS R01 HL081572NIDDK NIH HHS R01 DK116603NIH HHS R01HL081572
6 · The paper itself

Abstract

backgroundCalcium (Ca) is an essential nutrient that may play an important role in weight maintenance through its involvement in energy or lipid metabolism. However, little is known about the long-term associations of Ca intake with obesity risk.

objectivesWe aimed to prospectively examine the association between cumulative Ca intake and the incidence of obesity among American young adults over 30 y of follow-up.

methodsParticipants were from the CARDIA (Coronary Artery Risk Development in Young Adults) study. A total of 4097 of 5115 black and white individuals aged 18-30 y at baseline in 1985-1986 were included in the current analysis. Dietary and supplemental Ca intake was assessed by the validated interview-based CARDIA diet history at baseline and exam years 7 and 20. Incident cases of obesity were identified when BMI was ≥30 kg/m2 for the first time since baseline. A survival analysis was performed using Cox proportional hazards regression models to estimate the HRs and corresponding 95% CIs for obesity incidence during follow-up.

resultsDuring a 30-y follow-up (mean ± SD: 20 ± 10 y), 1675 participants developed obesity. Cumulative total Ca intake (dietary plus supplemental Ca) was inversely associated with incidence of obesity in multivariable-adjusted analysis [quintile (Q)5 (highest intake) compared with Q1 (lowest intake): HR: 0.68; 95% CI: 0.56, 0.82; P-trend < 0.01]. This inverse association persisted among Ca supplement users (Q5 compared with Q1: HR: 0.53; 95% CI: 0.40, 0.70; P-trend < 0.01), but was not seen among nonusers.

conclusionsFollowing a cohort of Americans from young adulthood to midlife, an inverse association between calcium intake and obesity incidence was observed. Further studies are needed to confirm our findings.

Indexed as

CalciumDietAdultFollow-Up StudiesHumansIncidenceObesityProportional Hazards ModelsProspective StudiesRisk FactorsUnited StatesYoung AdultCalciumcalciumCARDIA cohortdietobesitysupplement

Identifiers

PMID33978165
PMCPMC8435995
OpenAlexW3160409374

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.