Trial reportClinics (Sao Paulo, Brazil)2021
A randomized controlled study on an integrated approach to prevent and treat re-adhesion after transcervical resection of moderate-to-severe intrauterine adhesions.
Trial report in Clinics (Sao Paulo, Brazil), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Comparing durations of intrauterine balloon placement for intrauterine adhesions after hysteroscopic surgery: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- The epidemiology, clinical burden, and prevention of intrauterine adhesions (IUAs) related to surgically induced endometrial trauma: a systematic literature review and selective meta-analyses.Human reproduction update · 2025Pooled it
- Effect of magnetic thermal vibration therapy combined with Femoston on endometrial repair in postoperative patients with moderate to severe intrauterine adhesions: a randomized controlled trial.Frontiers in endocrinology · 2026Trial
- Establishment of a mouse intrauterine adhesion model via transvaginal mechanical injury guided by abdominal ultrasound.PloS one · 2026Article
- Prognostic Factors and Predictive Models for Reproductive Outcomes in Patients with Intrauterine Adhesions: A Review.International journal of women's health · 2026Review
- The "habitat-phytochemistry-pharmacological effect" nexus: a multidimensional review of ethnomedicinalFrontiers in pharmacology · 2026Review
- A randomized clinical trial of surgical intervention with or without acupuncture combined with traditional Chinese medicine to treat intrauterine adhesions.Contemporary clinical trials communications · 2025Article
- Establishment and comparison of different procedures for modeling intrauterine adhesion in rats: A preliminary study.Heliyon · 2024Article
- Long-term effects of hysteroscopic adhesiolysis on postoperative pregnancy rates and fertility outcomes in patients with intrauterine adhesions.American journal of translational research · 2024Article
- Repairing and Regenerating Injured Endometrium Methods.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Visual Analysis of Uterine Adhesion Research Based on CiteSpace: Bibliometric Analysis From 2006 to 2021.Frontiers in reproductive health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to compare the clinical efficacy of an integrated approach to prevent and treat the recurrence of moderate-to-severe intrauterine adhesions (IUA) after hysteroscopic transcervical resection of adhesion (TCRA).
methodsThe study included a total of 70 patients with moderate-to-severe IUAs who underwent TCRA. Patients were randomly divided into two groups: treatment group (n=35) and control group n=35). In the treatment group, patients underwent balloon uterine stent placement and artificial cycle as well as received intrauterine perfusion of Danshen injection and oral Chinese medicine. In the control group, patients underwent balloon uterine stent placement and artificial cycle as well as received hyaluronic acid sodium and intrauterine device (IUD). Follow-up was performed after treatment of uterine cavity, menstruation and pregnancy.
resultsAfter 3 months of treatment, we observed a significantly lower rate of intrauterine re-adhesion (45.71% versus 77.14%, p=0.044) and significantly higher clinical efficiency (82.86% versus 77.14%, p=0.025) in the treatment group than those in the control group. After 6 months of treatment, we observed a significantly higher clinical efficiency in the treatment group than that in the control group (88.57% versus 68.57%, p=0.039). During the follow-up period, the pregnancy rate was 45.71% and 37.14% in the treatment group and control group, respectively, although the difference was not statistically significant (p=0.628).
conclusionsAfter surgical management of IUA, the integrated treatment combining a uterus stent placement and artificial cycle with Danshen injection and oral Chinese medicine can improve the condition of menstruation, and prevent and treat recurrence of IUA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.