ArticleOphthalmic epidemiology2022
Tutorial on Biostatistics: Receiver-Operating Characteristic (ROC) Analysis for Correlated Eye Data.
Article in Ophthalmic epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 19 citations in OpenAlex.
- Baseline Predictors for the Postoperative Trachomatous Trichiasis Following Lid Rotation Surgery in the FLuorometholone as Adjunctive MEdical Therapy for Trachomatous Trichiasis Surgery (FLAME) Trial.Ophthalmic epidemiology · 2026Trial
- Hybrid CNN-Transformer Framework for Molecular Imaging-based Early Alzheimer's Disease Detection.Molecular imaging and biology · 2026Article
- Comparative Diagnostic Performance of Serum α-Klotho and FGF-23 in Predicting Obstructive Sleep Apnea Severity: A Novel Biomarker Approach.Journal of clinical medicine · 2026Article
- Comparison of visual evoked potential variability in eyes affected by optic neuritis and fellow eyes.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Risk factors associated with beta-peripapillary atrophy in individuals of African ancestry with primary open-angle glaucoma.Eye (London, England) · 2025Article
- Macular Deep Capillary Plexus Ischemia as a Biomarker for Identifying Referable Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- High-Resolution Microperimetry for Detecting Glaucomatous Damage: A Prospective Evaluation of Performance.Clinical & experimental ophthalmology · 2025Article
- Multicenter evaluation of machine and deep learning methods to predict glaucoma surgical outcomes.Frontiers in artificial intelligence · 2025Article
- Predicting Glaucoma Surgical Outcomes Using Neural Networks and Machine Learning on Electronic Health Records.Translational vision science & technology · 2024Article
- Baseline characteristics of eyes with early residual fluid post loading phase of aflibercept therapy in neovascular AMD: PRECISE study report 3.Eye (London, England) · 2024Article
- Identifying Individuals at High Risk for HIV and Sexually Transmitted Infections With an Artificial Intelligence-Based Risk Assessment Tool.Open forum infectious diseases · 2024Article
- Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma.International journal of ophthalmology · 2024Article
- Inner retinal layers' alterations of the microvasculature in early stages of Parkinson's disease: a cross sectional study.International ophthalmology · 2023Article
- Development and international validation of custom-engineered and code-free deep-learning models for detection of plus disease in retinopathy of prematurity: a retrospective study.The Lancet. Digital health · 2023Article
- Characteristics of Design and Analysis of Ophthalmic Randomized Controlled Trials: A Review of Ophthalmic Papers 2020-2021.Ophthalmology science · 2023Article
- Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's disease.Neurobiology of aging · 2023Article
- Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
purposeTo demonstrate methods for receiver-operating characteristic (ROC) analysis of correlated eye data.
methodsWe applied the Obuchowski's nonparametric approach and cluster bootstrap for estimating and comparing the area under ROC curve (AUC) between different sets of predictors to three datasets with varying inter-eye correlation.
resultsIn an optic neuritis (ON) study of 152 eyes (80 patients), the AUC of optical coherence tomography retinal nerve fiber layer thickness for diagnosing ON (inter-eye kappa = 0.13) was 0.71 [95% confidence interval (95% CI): 0.622, 0.792] from the naïve approach without accounting for inter-eye correlation was narrower than from nonparametric (95% CI: 0.613, 0.801) or cluster bootstrap (95% CI: 0.614, 0.797) approaches. In an analysis of 198 eyes (135 patients), the baseline Age-related Eye disease Study scale predicted 5-year incidence of advanced age-related macular degeneration (inter-eye kappa = 0.23) with AUC of 0.72. The 95% CI from the naïve approach was slightly narrower (0.645, 0.794) than from the nonparametric (0.641, 0.797) or cluster bootstrap (0.641, 0.793) approaches. In an analysis of 1542 eyes (771 infants), birthweight and gestational age predicted treatment-requiring retinopathy of prematurity (inter-eye kappa = 0.98) with AUC of 0.80. Furthermore, the 95% CI from the naïve approach was narrower (0.769, 0.835) than from the nonparametric (0.755, 0.848) or cluster bootstrap (0.755, 0.845) approaches. 95% CIs for AUC differences between different models were narrower in the naïve approach than the nonparametric or cluster bootstrap approaches.
conclusionIn ROC analysis of correlated eye data, ignoring inter-eye correlation leads to narrower 95% CI with underestimation dependent on magnitude of inter-eye correlation. Nonparametric and cluster bootstrap approaches properly account for inter-eye correlation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.