ArticleStress and health : journal of the International Society for the Investigation of Stress2022
Associations between beta-blocker use and psychological distress in bereaved adults with cardiovascular conditions.
Article in Stress and health : journal of the International Society for the Investigation of Stress, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Do beta-blockers reduce negative intrusive thoughts and anxiety in cancer survivors? - An emulated trial.BMC cancer · 2024Observational
- Psychological stress and cardiovascular risk among women in Brazilian communities: a cross-sectional study.Cadernos de saude publica · 2024Article
- Impact of Vitamin D Deficiency on Mental Health in University Students: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
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6 authors.
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Abstract
The death of a close other is a major life stressor that disrupts mental and physical health. Beta-blocker medications are indicated treatments for cardiovascular conditions that may also mitigate psychological distress in the context of stressors by reducing adrenergic activity. We sought to examine observational links between beta-blocker medication use and psychological distress during bereavement. Using publicly available data from the Midlife in the United States Refresher study, we examined associations between beta-blocker use and general distress, depressive symptoms, and anxiety symptoms (as measured by the Mood and Anxiety Symptom Questionnaire) among bereaved adults with cardiovascular conditions (n = 161) using t-tests and regression models. Beta-blocker users reported lower levels of anxiety-related general distress (b = -2.49, SE = 0.88, p = 0.005) and depression-related general distress than non-users (b = -2.39, SE = 1.14, p = 0.039) in multivariate linear regression models adjusting for demographic characteristics, mental health treatments, time since loss and comorbid health conditions. These observed links between beta-blockers and lower psychological distress in bereavement warrant further investigation in prospective and randomized studies, as beta-blockers could be a scalable intervention for mitigating distress following loss.
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