Evidence map›Paper›PMID 33977645›Full record

ReviewThe FEBS journal2022

Interpreting the role of the striatum during multiple phases of motor learning.

Stefano Cataldi, Adrien T Stanley, Maria Concetta Miniaci, David Sulzer

Open access · greenAbstract readReview
In one paragraph

Review in The FEBS journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Stefano CataldiDepartments of Psychiatry, Neurology, Pharmacology, Biology, Columbia University, New York, NY, USA.ORCID 0000-0001-7708-4124
Adrien T StanleyDepartments of Psychiatry, Neurology, Pharmacology, Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-3870-1422
Maria Concetta MiniaciDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Italy.ORCID 0000-0003-3844-0581
David SulzerDepartments of Psychiatry, Neurology, Pharmacology, Biology, Columbia University, New York, NY, USA.ORCID 0000-0001-7632-0439
New York Psychoanalytic Society and Institute · USUniversity of Naples Federico II · IT

Funding

The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
Development of Fluorescent False NeurotransmittersR01MH108186 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SAMES, DALIBOR, SULZER, DAVID · 2015 to 2024
$5.8M
Autoimmune Features of Neurodegenerative DisordersR01NS095435 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SETTE, ALESSANDRO, SULZER, DAVID · 2018 to 2022
$4.2M
Chemical Targeting of Sensors and Pharmacological Probes in the BrainR01MH122470 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SAMES, DALIBOR, SULZER, DAVID · 2020 to 2023
$2.3M
NIDA NIH HHS R01 DA007418NIMH NIH HHS R01 MH108186NIMH NIH HHS R01 MH122470NINDS NIH HHS R01 NS095435
6 · The paper itself

Abstract

The synaptic pathways in the striatum are central to basal ganglia functions including motor control, learning and organization, action selection, acquisition of motor skills, cognitive function, and emotion. Here, we review the role of the striatum and its connections in motor learning and performance. The development of new techniques to record neuronal activity and animal models of motor disorders using neurotoxin, pharmacological, and genetic manipulations are revealing pathways that underlie motor performance and motor learning, as well as how they are altered by pathophysiological mechanisms. We discuss approaches that can be used to analyze complex motor skills, particularly in rodents, and identify specific questions central to understanding how striatal circuits mediate motor learning.

Indexed as

Basal GangliaCorpus StriatumAnimalsbasal gangliadirect pathwayindirect pathwaymotor learningstriatum

Identifiers

PMID33977645
PMCPMC8590810
OpenAlexW3160252573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.