Evidence map›Paper›PMID 33977581›Full record

ArticleMagnetic resonance in medicine2021

Phase contrast coronary blood velocity mapping with both high temporal and spatial resolution using triggered Golden Angle rotated Spiral k-t Sparse Parallel imaging (GASSP) with shifted binning.

Dan Zhu, Gabriele Bonanno, Allison G Hays, Robert G Weiss, Michael Schär

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Ultrafast Blood TMagnetic resonance in medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dan ZhuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0940-1519
Gabriele BonannoRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7761-5308
Allison G HaysRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert G WeissRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michael SchärRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7044-9941
Johns Hopkins University · US

Funding

CONTRIBUTION OF ENERGY DEPLETION TO HUMAN HEART FAILURER01HL061912 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 1999 to 2020
$8.0M
Inflammation and Coronary Endothelial FunctionR01HL120905 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2015 to 2018
$2.4M
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIVR01HL125059 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2015 to 2017
$2.4M
Emerging factors in the pathophysiology of endothelial dysfunction in HIV+ womenR01HL147660 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HAYS, ALLISON G · 2019 to 2023
$1.4M
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIVR56HL125059 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2014 to 2014
$626k
American Heart Association 17SDG33671007NHLBI NIH HHS R01 HL061912NHLBI NIH HHS R01 HL120905NHLBI NIH HHS R01 HL125059NHLBI NIH HHS R01 HL147660NHLBI NIH HHS R56 HL125059NIH HHS HL120905NIH HHS HL125059NIH HHS HL61912the District of Columbia Women's Board (DCWB)
6 · The paper itself

Abstract

purposeHigh temporal and spatial resolutions are required for coronary blood flow measures. Current spiral breath-hold phase contrast (PC) MRI at 3T focus on either high spatial or high temporal resolution. We propose a golden angle (GA) rotated Spiral k-t Sparse Parallel imaging (GASSP) sequence for both high spatial (0.8 mm) and high temporal (<21 ms) resolutions.

methodsGASSP PC data are acquired in left anterior descending and right coronary arteries of eight healthy subjects. Binning of GA rotated spiral data into cardiac frames may lead to large k-space gaps. To reduce those gaps, the binning window is shifted and a triggered GA scheme that resets the rotation angle every heartbeat is proposed. The gap reductions are evaluated in simulations and all subjects. Peak systolic velocity (PSV), peak diastolic velocity (PDV), coronary blood flow rate, and vessel area are validated against two reference scans, and repeatability/reproducibility are determined.

resultsShifted binning reduced the mean k-space gaps of the triggered GA scheme by 14°-22° in simulations and about 20° in vivo. The k-space gap across three cardiac frames was reduced with the triggered GA scheme compared to the standard GA scheme (35.3°± 3.6° vs. 43°± 13.7°, t-test P = .04). PSV, PDV, flow rate, and area had high intra-scan repeatability (0.92 ≤ intraclass correlation coefficient [ICC] ≤ 0.99), and inter-scan (0.78 ≤ ICC ≤ 0.91) and intra-observer (0.91 ≤ ICC ≤ 0.98) reproducibility.

conclusionGASSP enables single breath-hold coronary PC MRI with high temporal and spatial resolutions. Shifted binning and a triggered GA scheme reduce k-space gaps. Quantitative coronary flow metrics are highly reproducible, especially within the same scanning session.

Indexed as

Breath HoldingCoronary VesselsBlood Flow VelocityHumansMagnetic Resonance ImagingReproducibility of ResultsSystolecoronary flowcoronary MRIcoronary velocitygolden anglek-t sparse SENSEspiral MRI

Identifiers

PMID33977581
PMCPMC8295217
OpenAlexW3160281544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.