Evidence map›Paper›PMID 33977531›Full record

SynthesisExperimental dermatology2021

A systematic review of the histopathologic survey on skin biopsies in patients with Corona Virus Disease 2019 (COVID-19) who developed virus or drug-related mucocutaneous manifestations.

Niloufar Najar Nobari, Farnoosh Seirafianpour, Milad Dodangeh, Afsaneh Sadeghzadeh-Bazargan, Elham Behrangi, Samaneh Mozafarpoor, Azadeh Goodarzi

Abstract readSystematic Review
In one paragraph

Synthesis in Experimental dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Review
  5. Observational
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  15. The effect of opium on severity of COVID-19 infection:An original study from Iran.Medical journal of the Islamic Republic of Iran · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Niloufar Najar NobariDepartment of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.ORCID 0000-0002-4245-1980
Farnoosh SeirafianpourStudent Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-3794-6206
Milad DodangehStudent Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-6974-7346
Afsaneh Sadeghzadeh-BazarganDepartment of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.ORCID 0000-0003-1102-6241
Elham BehrangiDepartment of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.ORCID 0000-0002-6545-3460
Samaneh MozafarpoorDepartment of Dermatology, Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0001-9417-4295
Azadeh GoodarziDepartment of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.ORCID 0000-0002-1249-4429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mucocutaneous manifestations of Corona Virus Disease 2019 (COVID-19) logically may reflect systemic visceral involvements. These findings are visible and easy to approach like biopsies for exact histopathologic evaluations. This systematic review was conducted to collect the mucocutaneous histopathologic data of COVID-19 patients for future investigations and interpretations. The COVID-19 dermatology resource of the Centre of Evidence-Based Dermatology (CEBD) at the University of Nottingham, PubMed, Scopus, Google Scholar and Medscape was searched for relevant English articles published by June 3, 2020. This review included 31 articles, involving 459 patients. The common primary virus-related mucocutaneous manifestations are easy to approach in the course of COVID-19. The authors of this study supposed dermatopathological findings as the predictors of the nature of potential systemic involvements and outcomes of COVID-19. Scrutinizing these findings can help with adopting more effective therapeutic and management strategies; nevertheless, this review found the severity and time of onset of symptoms not to be associated with the laboratory and histopathological findings. Deterioration of clinical conditions and laboratory tests was also not related to the histopathological findings. It is recommended that meta-analyses be conducted in the future to detail on these data for having more comprehensive and better conclusion.

Indexed as

BiopsyCOVID-19Drug EruptionsHumansMucous MembraneSARS-CoV-2SkinSkin DiseasesbiopsycoronavirusCOVID-19cutaneousdermatologyhistopathologymucocutaneouspathologySARS-CoV-2skinsystematic review

Identifiers

PMID33977531
PMCPMC8239817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.