Evidence map›Paper›PMID 33977527›Full record

ArticleFEBS letters2021

Mice lacking endogenous TRPV1 express reduced levels of thermogenic proteins and are susceptible to diet-induced obesity and metabolic dysfunction.

Padmamalini Baskaran, Kara Nazminia, Justine Frantz, Jessica O'Neal, Baskaran Thyagarajan

Open access · greenAbstract read
In one paragraph

Article in FEBS letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. The Role of Cannabidiol in Liver Disease: A Systemic Review.International journal of molecular sciences · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Padmamalini BaskaranMolecular Signaling Laboratory, School of Pharmacy, University of Wyoming, Laramie, WY, USA.
Kara NazminiaMolecular Signaling Laboratory, School of Pharmacy, University of Wyoming, Laramie, WY, USA.
Justine FrantzMolecular Signaling Laboratory, School of Pharmacy, University of Wyoming, Laramie, WY, USA.
Jessica O'NealMolecular Signaling Laboratory, School of Pharmacy, University of Wyoming, Laramie, WY, USA.
Baskaran ThyagarajanMolecular Signaling Laboratory, School of Pharmacy, University of Wyoming, Laramie, WY, USA.ORCID 0000-0002-4757-6125
University of Wyoming · US

Funding

Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Nicolas A. Blouin · 2012 to 2026
$56.8M
NIGMS NIH HHS P20 GM103432
6 · The paper itself

Abstract

Transient receptor potential vanilloid subfamily 1 (TRPV1) is a non-selective cation channel protein expressed in neuronal and non-neuronal cells. Although TRPV1 is implicated in thermogenesis and diet-induced obesity (DIO), its precise role remains controversial. TRPV1

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteAnimalsDiet, High-FatDisease Models, AnimalGene Expression RegulationGene Knockdown TechniquesGene Regulatory NetworksMaleMetabolic SyndromeMiceObesityThermogenesisTRPV Cation ChannelsTRPV1 protein, mouseTRPV Cation Channelsadipose tissueadiposityfatty livermetabolismobesityTRPV1−/−

Identifiers

PMID33977527
PMCPMC8277693
OpenAlexW3163596471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.