Evidence map›Paper›PMID 33977493›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Ras, Ral, and Rap1 in C. elegans.

Neal R Rasmussen, David J Reiner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Neal R RasmussenInstitute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
David J ReinerInstitute of Biosciences and Technology, Texas A&M University, Houston, TX, USA. dreiner@tamu.edu.
Texas A&M University · US

Funding

Novel signals regulate cell fate patterning - Equipment SupplementR01GM121625 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI REINER, DAVID · 2017 to 2020
$1.4M
Global changes in the 3'UTRome toggle responsiveness to growth factorsR21HD090707 · NICHD · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MANGONE, MARCO, REINER, DAVID · 2017 to 2018
$422k
NICHD NIH HHS R21 HD090707NIGMS NIH HHS R01 GM121625
6 · The paper itself

Abstract

Characterizing the consequences of mutated Ras/LET-60 on the development of the C. elegans vulva has provided critical insights into the role of Ras in normal animal development. Furthermore, double mutant analysis revealed the role of Ras relative to other components of growth factor signal transduction. Here we describe the combined use of principles of parallelism and epistasis to investigate the use of different Ras effectors, Raf and RalGEF > Ral, during the development of the vulva and other tissues. We additionally describe the use of these principles to delineate the function of the close Ras relative, RAP-1. The worm continues to lead the way in clarifying otherwise poorly understood functions of Ras during animal development.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCaenorhabditis elegansFemaleral GTP-Binding Proteinsrap1 GTP-Binding Proteinsras ProteinsSignal TransductionVulvaral GTP-Binding Proteinsrap1 GTP-Binding Proteinsras ProteinsEGFEGFRERKFGFFGFRLIN-45MAP kinaseMPK-1RAL-1RGL-1

Identifiers

PMID33977493
PMCPMC12771541
OpenAlexW3160420875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.