Evidence map›Paper›PMID 33977478›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Understanding Ras Spatial Cycles Through Reaction-Diffusion Simulations.

Malte Schmick, Philippe I H Bastiaens

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Malte SchmickDepartment of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
Philippe I H BastiaensDepartment of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany. philippe.bastiaens@mpi-dortmund.mpg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reaction-diffusion simulations allow us to recapitulate experimentally observed behavior, e.g., from time series of fluorescent micrographs. This is essential to inform our intuitive understanding of the chemical and biophysical interaction of proteins in a cellular context as well as their role in reaction networks. This chapter aims to give a brief introduction to setting up reaction-diffusion simulations and applies these in silico techniques to take apart the spatial cycles that maintain Ras localization in the cell.

Indexed as

Computer SimulationModels, BiologicalSpatial AnalysisDiffusionGuanosine TriphosphateHumansras ProteinsGuanosine Triphosphateras ProteinsIntracellular protein localizationNumerical reaction-diffusion simulationPredictive mathematical modelingRas spatial cyclesSimulation-aided pharmacological interferenceSmall G proteinSmall molecule inhibitor

Identifiers

PMID33977478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.