Evidence map›Paper›PMID 33977457›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Production, Detection, Extraction, and Quantification of Polyene Antibiotics.

Eva G Barreales, Jesús F Aparicio

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Natural Products Biosynthesis byAntibiotics (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eva G BarrealesArea of Microbiology, Faculty of Biology, University of León, León, Spain.
Jesús F AparicioArea of Microbiology, Faculty of Biology, University of León, León, Spain. jesus.aparicio@unileon.es.
Universidad de León · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyene antibiotics are macrolide antifungal compounds obtained by fermentation of producer Streptomyces strains. Here we describe commonly used methods for polyene production, detection, and their subsequent extraction and purification. While bioassays are used to detect these compounds based on their biological activity, quantification by spectrophotometry or high-performance liquid chromatography (HPLC ) relies on their physiochemical properties and is more reliable.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBiological AssayChromatography, High Pressure LiquidFermentationMacrolidesPolyenesStreptomycesAnti-Bacterial AgentsAntifungal AgentsMacrolidesPolyenesAntifungal agentBioassayHPLCPolyene macrolideStreptomycesUV-visible spectrum

Identifiers

PMID33977457
OpenAlexW3160543459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.