Evidence map›Paper›PMID 33977395›Full record

ArticleMikrochimica acta2021

An iron oxide nanoworm hybrid on an interdigitated microelectrode silica surface to detect abdominal aortic aneurysms.

Guangjun Yan, Qingchun Li, Xingyu Hong, Subash C B Gopinath, Periasamy Anbu, Chang Li, Mei Ding

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Article in Mikrochimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Guangjun Yan *Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China.
Qingchun Li *Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China.
Xingyu HongDepartment of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China.
Subash C B GopinathFaculty of Chemical Engineering Technology, Universiti Malaysia Perlis (UniMAP), Arau, Perlis, Malaysia.
Periasamy AnbuDepartment of Biological Engineering, College of Engineering, Inha University, Incheon, 402-751, Republic of Korea.
Chang LiDepartment of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China. lichangsky@sina.cn.ORCID 0000-0002-6921-9575
Mei DingDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory for Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin, 130031, China. dm20191231@sina.com.
Jilin University · CNInha University · KRUnion Hospital · CNUniversiti Malaysia Perlis · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An abdominal aortic aneurysm (AAA) is abnormal swelling in the abdominal aorta and a prevalent life-threatening disease. This research introduces a new interdigitated microelectrode (IDME)-sensing surface modified by iron oxide nanoworms (IONWs) for detecting the AAA biomarker insulin-like growth factor-1 (IGF1). A sandwich pattern was formulated with the IGF1 aptamer and IGFBP1 (IGF binding protein-1) on the IONW-constructed IDME hybrid to identify IGF1. The surface morphology of the IONWs revealed a uniform distribution of worm-like structures (80-100 nm) as confirmed by FESEM and FETEM analyses. Further, the presence of the major elements, Fe and O, was confirmed by EDX and XPS studies. The crystal planes that appeared in the IONW reflect cubic magnetite. IONW-modified IDME attained a limit of detection for IGF1 of 1 fM (3σ) with an aptamer-IGF1-IGFBP1 sandwich. This sandwich with IGFBP1 enhanced the current level at all concentrations of IGF1 and displayed linearity in the range 1 fM to 100 pM with a determination coefficient of R

Indexed as

Aortic Aneurysm, AbdominalAptamers, NucleotideBiomarkersBiosensing TechniquesElectrochemical TechniquesFerrous CompoundsHumansImmobilized Nucleic AcidsInsulin-Like Growth Factor ILimit of DetectionMicroelectrodesNanostructuresAptamers, NucleotideBiomarkersFerrous Compoundsferrous oxideIGF1 protein, humanImmobilized Nucleic AcidsInsulin-Like Growth Factor IAortic aneurysmBiomarkerElectrochemical detection; DielectrodeInsulin-like growth factorIron oxide

Identifiers

PMID33977395
OpenAlexW3163566607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.