Evidence map›Paper›PMID 33977285›Full record

ReviewFaculty reviews2021

Adipotropic effects of heavy metals and their potential role in obesity.

Alexey A Tinkov, Michael Aschner, Tao Ke, Beatriz Ferrer, Ji-Chang Zhou, Jung-Su Chang, Abel Santamaría, Jane C-J Chao, Jan Aaseth, Anatoly V Skalny

Open access · diamondAbstract readReview
In one paragraph

Review in Faculty reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Heavy metals as endocrine disruptors.Turkish journal of medical sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Metal mixtures and adiposity indicators in women from Northern Mexico.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  13. Mercury toxicity resulting from enzyme alterations- minireview.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Correlates of whole blood metal concentrations among reproductive-aged Black women.Journal of exposure science & environmental epidemiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 6 countries.

Alexey A TinkovIM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Michael AschnerIM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.ORCID https://orcid.org/0000-0002-2619-1656
Tao KeDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
Beatriz FerrerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
Ji-Chang ZhouSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Jung-Su ChangTaipei Medical University, Taipei, Taiwan.
Abel SantamaríaLaboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, S.S.A., Mexico City, Mexico.
Jane C-J ChaoTaipei Medical University, Taipei, Taiwan.
Jan AasethIM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Anatoly V SkalnyIM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Albert Einstein College of Medicine · USSechenov University · RUInstituto Nacional de Neurología y Neurocirugía · MXSun Yat-sen University · CNTaipei Medical University · TWTaipei Medical University Hospital · TW

Funding

Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
NIEHS NIH HHS R01 ES007331
6 · The paper itself

Abstract

Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury, cadmium, and lead) and metalloid (arsenic) on adipose tissue physiology are discussed while considering existing gaps and contradictions. Here, we provide a literature review addressing adipose tissue as a potential target of heavy metal toxicity. Experimental

Indexed as

adipocyteadipogenesiscadmiumleadmercury

Identifiers

PMID33977285
PMCPMC8103910
OpenAlexW3149762145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.