ArticleBrain communications2021
Inhibitory control in children with tic disorder: aberrant fronto-parietal network activity and connectivity.
Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Inhibitory Control Development: A Network Neuroscience Perspective.Frontiers in psychology · 2022Pooled it
- Perturbation-evoked cortical responses and altered causal information flow reflect more effortful but less efficient postural control in patients after ACLR.Scientific reports · 2026Article
- Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping.NeuroImage · 2025Article
- Dynamic modulations of effective brain connectivity associated with postural instability during multi-joint compound movement on compliant surface.Experimental brain research · 2025Article
- Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome.Brain communications · 2025Article
- Motor network organization in healthy development and chronic tic disorders.Brain communications · 2025Article
- Diffusion indices alteration in major white matter tracts of children with tic disorder using TRACULA.Journal of neurodevelopmental disorders · 2024Article
- Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.Neuroscience applied · 2024Review
- Visual stimulus structure, visual system neural activity, and visual behavior in young human infants.PloS one · 2024Article
- Electroencephalographic Effective Connectivity Analysis of the Neural Networks during Gesture and Speech Production Planning in Young Adults.Brain sciences · 2023Article
- Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Tourette syndrome research highlights from 2021.F1000Research · 2022Review
- Association of resting-state theta-gamma coupling with selective visual attention in children with tic disorders.Frontiers in human neuroscience · 2022Article
- Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic tic disorders, including Tourette syndrome, are typically thought to have deficits in cognitive inhibition and top down cognitive control due to the frequent and repetitive occurrence of tics, yet studies reporting task performance results have been equivocal. Despite similar behavioural performance, individuals with chronic tic disorder have exhibited aberrant patterns of neural activation in multiple frontal and parietal regions relative to healthy controls during inhibitory control paradigms. In addition to these top down attentional control regions, widespread alterations in brain activity across multiple neural networks have been reported. There is a dearth, however, of studies examining event-related connectivity during cognitive inhibitory paradigms among affected individuals. The goal of this study was to characterize neural oscillatory activity and effective connectivity, using a case-control design, among children with and without chronic tic disorder during performance of a cognitive inhibition task. Electroencephalogram data were recorded in a cohort of children aged 8-12 years old (60 with chronic tic disorder, 35 typically developing controls) while they performed a flanker task. While task accuracy did not differ by diagnosis, children with chronic tic disorder displayed significant cortical source-level, event-related spectral power differences during incongruent flanker trials, which required inhibitory control. Specifically, attenuated broad band oscillatory power modulation within the anterior cingulate cortex was observed relative to controls. Whole brain effective connectivity analyses indicated that children with chronic tic disorder exhibit greater information flow between the anterior cingulate and other fronto-parietal network hubs (midcingulate cortex and precuneus) relative to controls, who instead showed stronger connectivity between central and posterior nodes. Spectral power within the anterior cingulate was not significantly correlated with any connectivity edges, suggesting lower power and higher connectivity are independent (versus resultant) neural mechanisms. Significant correlations between clinical features, task performance and anterior cingulate spectral power and connectivity suggest this region is associated with tic impairment (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.