Evidence map›Paper›PMID 33977248›Full record

ArticleIJU case reports2021

Transcription factor 4 expression in circulating tumor cells from castration-resistant prostate cancer.

Naoya Nagaya, Geun Taek Lee, Yan Lu, Takeshi Ashizawa, Masayoshi Nagata, Isaac Yi Kim, Shigeo Horie

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IJU case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Naoya NagayaDepartment of Urology Juntendo University Graduate School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0003-4815-9240
Geun Taek LeeSection of Urologic Oncology Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.
Yan LuDepartment of Urology Juntendo University Graduate School of Medicine Tokyo Japan.
Takeshi AshizawaDepartment of Urology Juntendo University Graduate School of Medicine Tokyo Japan.
Masayoshi NagataDepartment of Urology Juntendo University Graduate School of Medicine Tokyo Japan.
Isaac Yi KimSection of Urologic Oncology Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.
Shigeo HorieDepartment of Urology Juntendo University Graduate School of Medicine Tokyo Japan.
Juntendo University · JPRutgers, The State University of New Jersey · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeuroendocrine differentiation is partly caused by antiandrogen therapy and exhibits an androgen receptor-independent growth mechanism. We hypothesized that the expression of transcription factor 4, an inducer of neuroendocrine differentiation, in circulating tumor cells is related to drug resistance in castration-resistant prostate cancer. CASE PRESENTATION: We evaluate the messenger ribonucleic acid expression of transcription factor 4 in circulating tumor cells from 17 patients with castration-resistant prostate cancer and compared these levels between patients receiving antiandrogen therapies and those who were resistant to antiandrogen therapies and receiving chemotherapies. The expression of transcription factor 4 in circulating tumor cells was significantly higher among patients receiving chemotherapies.

conclusionThis study shows that transcription factor 4 is higher in the group of patients who were judged by their physicians to need chemotherapy treatment.

Indexed as

androgen receptorcastration‐resistant prostate cancercirculating tumor cellsneuroendocrine differentiationtranscription factor 4

Identifiers

PMID33977248
PMCPMC8088892
OpenAlexW3138668529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.