Evidence map›Paper›PMID 33977233›Full record

ArticleFASEB bioAdvances2021

Upregulated expression of a subset of genes in

Mitsuru Shinohara, Masataka Kikuchi, Miyuki Onishi-Takeya, Yoshitaka Tashiro, Kaoru Suzuki, Yasuhiro Noda, Shuko Takeda, Masahiro Mukouzono, Seiichi Nagano, Akio Fukumori and 3 more

Open access · goldAbstract read
In one paragraph

Article in FASEB bioAdvances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Journal of neurology, neurosurgery, and psychiatry · 2023
    Article
  7. Obesity impacts the expression of Alzheimer's disease-related genes: The Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mitsuru ShinoharaDepartment of Aging Neurobiology Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.
Masataka KikuchiDepartment of Genome Informatics Graduate School of Medicine Osaka University Osaka Japan.
Miyuki Onishi-TakeyaDepartment of Geriatric Medicine Graduate School of Medicine Osaka University Osaka Japan.
Yoshitaka TashiroDepartment of Aging Neurobiology Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.
Kaoru SuzukiDepartment of Aging Neurobiology Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.
Yasuhiro NodaDepartment of Aging Neurobiology Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.
Shuko TakedaDepartment of Clinical Gene Therapy Graduate School of Medicine Osaka University Osaka Japan.
Masahiro MukouzonoDepartment of Clinical Gene Therapy Graduate School of Medicine Osaka University Osaka Japan.
Seiichi NaganoDepartment of Neurology Graduate School of Medicine Osaka University Osaka Japan.
Akio FukumoriDepartment of Aging Neurobiology Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.
Ryuichi MorishitaDepartment of Clinical Gene Therapy Graduate School of Medicine Osaka University Osaka Japan.
Akihiro NakayaDepartment of Genome Informatics Graduate School of Medicine Osaka University Osaka Japan.
Naoyuki SatoDepartment of Aging Neurobiology Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Aichi Japan.
Osaka University · JPNational Center for Geriatrics and Gerontology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies have indicated that obesity and diabetes are associated with Alzheimer's disease (AD) and neurodegeneration. However, the mechanism by which obesity/diabetes and AD interact with each other and contribute to dementia remains elusive. To obtain insights into their interaction at molecular levels, we performed gene expression analysis of

Indexed as

Alzheimer's diseaseanimal modelsdiabetesinteractionobesity

Identifiers

PMID33977233
PMCPMC8103720
OpenAlexW3134812752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.