Evidence map›Paper›PMID 33977229›Full record

ArticleIntegrative organismal biology (Oxford, England)2021

Defibrillate You Later, Alligator: Q10 Scaling and Refractoriness Keeps Alligators from Fibrillation.

Conner Herndon, Henry C Astley, Tomasz Owerkowicz, Flavio H Fenton

Open access · goldAbstract read
In one paragraph

Article in Integrative organismal biology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Optical mapping of contracting hearts.The Journal of physiology · 2023
    Review
  2. Methodological analysis of dual voltage-calcium whole-heart optical signals during restitution pacing under different thermal states.... Conference of the European Study Group on Cardiovascular Oscillations (ESGCO). European Study Group on Cardiovascular Oscillations. Conference · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Conner HerndonSchool of Physics, Georgia Institute of Technology, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-0787-0247
Henry C AstleyDepartment of Biology, Biomimicry Research & Innovation Center, University of Akron, Akron, OH, USA.
Tomasz OwerkowiczDepartment of Biology, California State University, San Bernardino, CA, USA.
Flavio H FentonSchool of Physics, Georgia Institute of Technology, Atlanta, GA, USA.
Georgia Institute of Technology · USCalifornia State University, San Bernardino · USUniversity of Akron · US

Funding

Integrative High-Resolution Experimental and Multiscale Modeling of Arrhythmias to Optimize Low Energy Anti-fibrillation Pacing (LEAP)R01HL143450 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Flavio H Fenton · 2018 to 2026
$3.2M
KITP Interdisciplinary Biology InitiativeR25GM067110 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SHRAIMAN, BORIS I · 2003 to 2018
$1.8M
NHLBI NIH HHS R01 HL143450NIGMS NIH HHS R25 GM067110
6 · The paper itself

Abstract

Effective cardiac contraction during each heartbeat relies on the coordination of an electrical wave of excitation propagating across the heart. Dynamically induced heterogeneous wave propagation may fracture and initiate reentry-based cardiac arrhythmias, during which fast-rotating electrical waves lead to repeated self-excitation that compromises cardiac function and potentially results in sudden cardiac death. Species which function effectively over a large range of heart temperatures must balance the many interacting, temperature-sensitive biochemical processes to maintain normal wave propagation at all temperatures. To investigate how these species avoid dangerous states across temperatures, we optically mapped the electrical activity across the surfaces of alligator (

Identifiers

PMID33977229
PMCPMC8101277
OpenAlexW3125700649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.