ArticleMovement disorders clinical practice2021
Incidence and Progression of Rapid Eye Movement Behavior Disorder in Early Parkinson's Disease.
Article in Movement disorders clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Polysomnographic Predictors of Sleep, Motor, and Cognitive Dysfunction Progression in Parkinson's Disease.Current neurology and neuroscience reports · 2022Pooled it
- Retinal Architecture in Parkinson's Disease with Rapid Eye Movement Sleep Behaviour Disorder: Insights from a Scoping Review.Annals of neurosciences · 2026Review
- Beyond RBD: covert REM sleep abnormalities in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- MRI structural and functional axial asymmetry in the brain-first versus body-first subtypes of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Novel technologies for REM sleep behavior disorder detection for home screening in Parkinson's disease and related alpha-synucleinopathies.NPJ Parkinson's disease · 2025Article
- Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson's disease with RBD.NPJ Parkinson's disease · 2025Article
- Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease.Annals of neurology · 2025Article
- Sleep Disturbance in Parkinson's Disease: Consequences for the Brain and Disease Progression - A Narrative Review.Nature and science of sleep · 2025Review
- Sleep-Related Disorders in Parkinson's Disease: Mechanisms, Diagnosis, and Therapeutic Approaches.CNS & neurological disorders drug targets · 2025Review
- Symmetric and Profound Monoaminergic Degeneration in Parkinson's Disease with Premotor REM Sleep Behavior Disorder.Journal of Parkinson's disease · 2024Article
- The Increasing Prevalence of REM Sleep Behavior Disorder with Parkinson's Disease Progression: A Polysomnography-Supported Study.Movement disorders clinical practice · 2023Article
- Correlation and underlying brain mechanisms between rapid eye movement sleep behavior disorder and executive functions in Parkinson's disease: an fNIRS study.Frontiers in aging neuroscience · 2023Article
- Longitudinal Studies of Sleep Disturbances in Parkinson's Disease.Current neurology and neuroscience reports · 2022Review
- Dysautonomia and REM sleep behavior disorder contributions to progression of Parkinson's disease phenotypes.NPJ Parkinson's disease · 2022Article
- Evolution patterns of probable REM sleep behavior disorder predicts Parkinson's disease progression.NPJ Parkinson's disease · 2022Article
- White matter microstructure in Parkinson's disease with and without elevated rapid eye movement sleep muscle tone.Brain communications · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid eye movement (REM) sleep behavior disorder (RBD) is associated with neurodegenerative diseases; however, few longitudinal studies assess the individual evolution of RBD and REM sleep without atonia (RWA) in Parkinson's disease (PD).
objectivesWe aimed to evaluate RBD and RWA changes over time as well as potentially influential factors.
methodsRBD and RWA were analyzed using video-supported polysomnography (vPSG) in initially de novo PD patients at baseline and every 2 years for a total of 6 years. The influence of time, age, sex, levodopa equivalent daily dose (LEDD), unified Parkinson's disease rating scale (UPDRS) sum scores, benzodiazepine intake, Mini-Mental State Examination (MMSE) total scores, and dyskinesia on RWA were investigated using mixed-effect models to account for intra-individual correlations.
resultsAfter 6 years, vPSG data were available from 98 of the initial 159 de novo PD patients. RBD prevalence increased from 25% at baseline to 52%. Of the 31 PD patients with RBD and valid vPSGs at all time-points, RWA increased from an average of 19% at baseline to 41% at 6-year follow-up modeled to grow by 29.7% every 2 years (
conclusionsRBD and RWA increased significantly over time in PD; time and age were independent factors in a prospective cohort. RBD and RWA can be considered PD progression markers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.