Evidence map›Paper›PMID 33977077›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

DeepVISP: Deep Learning for Virus Site Integration Prediction and Motif Discovery.

Haodong Xu, Peilin Jia, Zhongming Zhao

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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  6. DeepVISP: Deep Learning for Virus Site Integration Prediction and Motif Discovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Haodong XuCenter for Precision Health School of Biomedical Informatics The University of Texas Health Science Center at Houston (UTHealth) Houston TX 77030 USA.ORCID 0000-0003-2086-3893
Peilin JiaCenter for Precision Health School of Biomedical Informatics The University of Texas Health Science Center at Houston (UTHealth) Houston TX 77030 USA.
Zhongming ZhaoCenter for Precision Health School of Biomedical Informatics The University of Texas Health Science Center at Houston (UTHealth) Houston TX 77030 USA.
The University of Texas Health Science Center · USThe University of Texas MD Anderson Cancer Center · US

Funding

Transforming dbGaP genetic and genomic data to FAIR-ready by artificial intelligence and machine learning algorithmsR01LM012806 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongming Zhao · 2017 to 2026
$3.7M
NLM NIH HHS R01 LM012806
6 · The paper itself

Abstract

Approximately 15% of human cancers are estimated to be attributed to viruses. Virus sequences can be integrated into the host genome, leading to genomic instability and carcinogenesis. Here, a new deep convolutional neural network (CNN) model is developed with attention architecture, namely DeepVISP, for accurately predicting oncogenic virus integration sites (VISs) in the human genome. Using the curated benchmark integration data of three viruses, hepatitis B virus (HBV), human herpesvirus (HPV), and Epstein-Barr virus (EBV), DeepVISP achieves high accuracy and robust performance for all three viruses through automatically learning informative features and essential genomic positions only from the DNA sequences. In comparison, DeepVISP outperforms conventional machine learning methods by 8.43-34.33% measured by area under curve (AUC) value enhancement in three viruses. Moreover, DeepVISP can decode

Indexed as

Deep LearningCluster AnalysisGenome, HumanGenomic InstabilityHepatitis B virusHerpesvirus 1, HumanHerpesvirus 4, HumanHumansNeoplasmsOncogenic VirusesReproducibility of ResultsVirus Integrationcancerdeep learningEBVHBVHPVviruses

Identifiers

PMID33977077
PMCPMC8097320
OpenAlexW3134499419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.