ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.
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170citing papers in PubMed
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Who cites it
170 citing papers in PubMed.
- Reprogramming bone homeostasis: The recoupling-oriented framework of bidirectional regulation strategies for osteoporosis.iScience · 2026Review
- Bacterial small RNAs and extracellular vesicles in inflammatory and osteoimmune diseases: regulatory mechanisms and host-microbe communication.Archives of microbiology · 2026Review
- Research Progress on Mechanisms of Milk-Derived Functional Components in Regulating Bone Health and the Gut-Bone Axis.Nutrients · 2026Review
- Hesperetin mitigates IBD-associated bone loss viaJournal of orthopaedic translation · 2026Article
- Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging.Aging cell · 2026Review
- Probiotic supplementation promotes bone development, immune maturation, and cognitive function in growing mice.Journal of the science of food and agriculture · 2026Article
- Article
- Osteoporosis from the perspective of the gut-bone axis: gut microbiota, metabolites, and multi-system synergistic regulation.Journal of endocrinological investigation · 2026Review
- Vesicular Communication in the Bone-Muscle Unit: Physiological Functions, Aging, and Therapeutic Potential.Cells · 2026Review
- Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cold exposure-induced loss of beneficial gut bacterial sEV is associated with the pathogenesis of bone loss through pyroptosis pathway.Journal of nanobiotechnology · 2026Article
- SMN deficiency contributes to osteoporosis in spinal muscular atrophy by impairing Snap23 meditated muscle-derived extracellular vesicle secretion.Journal of translational medicine · 2026Article
- The gut-bone axis: impact of diet on gut microbiome and osteoporosis.Bone research · 2026Review
- Roseburia intestinalis-derived extracellular vesicles alleviate osteoporosis through gut microbiota-regulated histidylleucine via Akt/FOXO1 signaling.Communications biology · 2026Article
- Exosomes in bone health and disease: cellular crosstalk, systemic signaling, and AI-driven advances in regenerative therapy.Stem cell research & therapy · 2026Review
- Epigenetic brain reprogramming rejuvenates neuro-immune circuits to reverse Alzheimer's disease pathology and systemic bone loss.Journal of neuroinflammation · 2026Article
- Akkermansia muciniphila attenuates intervertebral disc degeneration via extracellular vesicle-mediated delivery of the effector protein B2UKX5.Bone research · 2026Article
- Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles.Cell reports. Medicine · 2026Article
- Engineered Akkermansia muciniphila extracellular vesicles for targeted delivery of miR-21-5p alleviate postmenopausal osteoporosis via PI3K-AKT pathway.Journal of nanobiotechnology · 2026Article
- Microbial messengers: decoding the gut microbiota's role in bone health through immunomodulation and exosomal signaling.NPJ biofilms and microbiomes · 2026Review
110 more citing papers are in PubMed but not listed here.
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Authors and funding
38 authors.
Jiang-Hua LiuDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Chun-Yuan ChenDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Zheng-Zhao LiuDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Zhong-Wei LuoDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Shan-Shan RaoDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Ling JinDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Teng-Fei WanDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Tao YueDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Yi-Juan TanDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Hao YinDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Fei YangDepartment of Occupational and Environmental Health Xiangya School of Public Health Central South University Changsha Hunan 410078 China.
Fei-Yu HuangDepartment of Occupational and Environmental Health Xiangya School of Public Health Central South University Changsha Hunan 410078 China.
Jian GuoDepartment of Occupational and Environmental Health Xiangya School of Public Health Central South University Changsha Hunan 410078 China.
Yi-Yi WangDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Kun XiaDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Jia CaoDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Zhen-Xing WangDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Chun-Gu HongMovement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China.
Ming-Jie LuoXiangya Nursing School Central South University Changsha Hunan 4100113 China.
Xiong-Ke HuDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Yi-Wei LiuMovement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China.
Wei DuDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Juan LuoMovement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China.
Yin HuDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Yan ZhangMovement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China.
Jie HuangDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Hong-Ming LiDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Ben WuDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Hao-Ming LiuDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Tuan-Hui ChenDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Yu-Xuan QianDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
You-You LiDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.
Shi-Kai FengMovement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China.
Yang ChenDepartment of Sports Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China.
Lu-Yue QiMovement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China.
Ran XuDepartment of Urology The Second Xiangya Hospital Central South University Changsha Hunan 410008 China.
Si-Yuan TangXiangya Nursing School Central South University Changsha Hunan 4100113 China.
Hui XieDepartment of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China.ORCID 0000-0002-8526-2637
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, the gut microbiota (GM) has been shown to be a regulator of bone homeostasis and the mechanisms by which GM modulates bone mass are still being investigated. Here, it is found that colonization with GM from children (CGM) but not from the elderly (EGM) prevents decreases in bone mass and bone strength in conventionally raised, ovariectomy (OVX)-induced osteoporotic mice. 16S rRNA gene sequencing reveals that CGM reverses the OVX-induced reduction of
Indexed as
AgedAge FactorsAnimalsBone and BonesBone DensityChild, PreschoolDisease Models, AnimalExtracellular VesiclesFemaleGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLMiddle AgedOsteoporosisAkkermansia muciniphilabone homeostasisextracellular vesiclesgut microbiota
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.