ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Bio-assembling Macro-Scale, Lumenized Airway Tubes of Defined Shape via Multi-Organoid Patterning and Fusion.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Organoids, organ-on-a-chip, and microtumors: Biomimetic 3D tumor models advancing drug development and precision medicine.Acta pharmaceutica Sinica. B · 2026Review
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- Cartilage repair: unleashing PRP's potential in organoid models.Cytotechnology · 2025Review
- KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells.American journal of respiratory cell and molecular biology · 2025Article
- Biofabrication methods for reconstructing extracellular matrix mimetics.Bioactive materials · 2024Review
- Biofabrication and biomanufacturing in Ireland and the UK.Bio-design and manufacturing · 2024Review
- Recapitulating the Drifting and Fusion of Two-Generation Spheroids on Concave Agarose Microwells.International journal of molecular sciences · 2023Article
- Polymer film-based microwell array platform for long-term culture and research of human bronchial organoids.Materials today. Bio · 2023Article
- Bioprinting microporous functional living materials from protein-based core-shell microgels.Nature communications · 2023Article
- Micron track chitosan conduit fabricated by 3D-printed model topography provides bionic microenvironment for peripheral nerve regeneration.International journal of bioprinting · 2023Article
- Apical-out airway organoids as a platform for studying viral infections and screening for antiviral drugs.Scientific reports · 2022Article
- Soluble ECM promotes organotypic formation in lung alveolar model.Biomaterials · 2022Article
- Emerging toolset of three-dimensional pulmonary cell culture models for simulating lung pathophysiology towards mechanistic elucidation and therapeutic treatment of SARS-COV-2 infection.Frontiers in pharmacology · 2022Review
- Mammary Tumor Organoid Culture in Non-Adhesive Alginate for Luminal Mechanics and High-Throughput Drug Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Ethical Challenges in Organoid Use.Biotech (Basel (Switzerland)) · 2021Article
- Bio-assembling Macro-Scale, Lumenized Airway Tubes of Defined Shape via Multi-Organoid Patterning and Fusion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- From niche to organoid: Engineering bone tissues through microenvironmental insights.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Epithelial, stem-cell derived organoids are ideal building blocks for tissue engineering, however, scalable and shape-controlled bio-assembly of epithelial organoids into larger and anatomical structures is yet to be achieved. Here, a robust organoid engineering approach, Multi-Organoid Patterning and Fusion (MOrPF), is presented to assemble individual airway organoids of different sizes into upscaled, scaffold-free airway tubes with predefined shapes. Multi-Organoid Aggregates (MOAs) undergo accelerated fusion in a matrix-depleted, free-floating environment, possess a continuous lumen, and maintain prescribed shapes without an exogenous scaffold interface. MOAs in the floating culture exhibit a well-defined three-stage process of inter-organoid surface integration, luminal material clearance, and lumina connection. The observed shape stability of patterned MOAs is confirmed by theoretical modelling based on organoid morphology and the physical forces involved in organoid fusion. Immunofluorescent characterization shows that fused MOA tubes possess an unstratified epithelium consisting mainly of tracheal basal stem cells. By generating large, shape-controllable organ tubes, MOrPF enables upscaled organoid engineering towards integrated organoid devices and structurally complex organ tubes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.