Evidence map›Paper›PMID 33977040›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Efficient Killing of Multidrug-Resistant Internalized Bacteria by AIEgens In Vivo.

Ying Li, Fei Liu, Jiangjiang Zhang, Xiaoye Liu, Peihong Xiao, Haotian Bai, Shang Chen, Dong Wang, Simon H P Sung, Ryan T K Kwok and 3 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Natural Acceptor of Coumarin-Isomerized Red-Emissive BioAIEgen for Monitoring CuAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  8. Complement C3 deposition restricts the proliferation of internalizedFrontiers in cellular and infection microbiology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Efficient Killing of Multidrug-Resistant Internalized Bacteria by AIEgens In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ying LiCenter for AIE Research College of Materials Science and Engineering Shenzhen University Shenzhen 518061 China.ORCID 0000-0002-9595-6296
Fei LiuNational Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University No. 2 Yuanmingyuan West Rd Beijing 100193 China.
Jiangjiang ZhangDepartment of Biomedical Engineering Southern University of Science and Technology No. 1088 Xueyuan Rd, Nanshan District Shenzhen 518055 China.
Xiaoye LiuNational Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University No. 2 Yuanmingyuan West Rd Beijing 100193 China.
Peihong XiaoCenter for AIE Research College of Materials Science and Engineering Shenzhen University Shenzhen 518061 China.
Haotian BaiDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study Division of Life Science The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Shang ChenNational Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University No. 2 Yuanmingyuan West Rd Beijing 100193 China.ORCID 0000-0002-4874-2922
Dong WangCenter for AIE Research College of Materials Science and Engineering Shenzhen University Shenzhen 518061 China.
Simon H P SungDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study Division of Life Science The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Ryan T K KwokDepartment of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study Division of Life Science The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
Jianzhong ShenNational Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University No. 2 Yuanmingyuan West Rd Beijing 100193 China.
Kui ZhuNational Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University No. 2 Yuanmingyuan West Rd Beijing 100193 China.ORCID 0000-0001-8242-3952
Ben Zhong TangCenter for AIE Research College of Materials Science and Engineering Shenzhen University Shenzhen 518061 China.ORCID 0000-0002-0293-964X
China Agricultural University · CNShenzhen University · CNHong Kong University of Science and Technology · HKSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria infected cells acting as "Trojan horses" not only protect bacteria from antibiotic therapies and immune clearance, but also increase the dissemination of pathogens from the initial sites of infection. Antibiotics are hard and insufficient to treat such hidden internalized bacteria, especially multidrug-resistant (MDR) bacteria. Herein, aggregation-induced emission luminogens (AIEgens) such as

Indexed as

AnimalsAnti-Bacterial AgentsDisease Models, AnimalDrug Resistance, Multiple, BacterialMethicillin-Resistant Staphylococcus aureusMiceQuaternary Ammonium CompoundsReactive Nitrogen SpeciesStaphylococcal Infections3-bromopropyltrimethylammonium bromideAnti-Bacterial AgentsQuaternary Ammonium CompoundsReactive Nitrogen Speciesaggregation‐induced emission luminogenantibioticautophagyinternalized bacteriaMRSA

Identifiers

PMID33977040
PMCPMC8097328
OpenAlexW3135800882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.