Evidence map›Paper›PMID 33976725›Full record

ArticleJournal of Cancer2021

MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN.

Jing Huang, Yaqin Zhang, Yuan Xu, Qi Xie, Shuang Wu, Yi Dong, Bing Chen, Yang Xia, Lili Guo, Qun Li and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jing HuangDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Yaqin ZhangDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Yuan XuDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Qi XieTranslational Research Institute, Henan Provincial People's Hospital, Molecular Pathology Center, Academy of Medical Science, Zhengzhou University, Zhengzhou, China, 450003.
Shuang WuDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Yi DongTranslational Research Institute, Henan Provincial People's Hospital, Molecular Pathology Center, Academy of Medical Science, Zhengzhou University, Zhengzhou, China, 450003.
Bing ChenTranslational Research Institute, Henan Provincial People's Hospital, Molecular Pathology Center, Academy of Medical Science, Zhengzhou University, Zhengzhou, China, 450003.
Yang XiaDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Lili GuoDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Qun LiDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Hao GuDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Wanglai HuDepartment of Immunology, the school of Basic Medical Sciences, Anhui Medical University, Hefei, China, 230032.
Anhui Medical University · CNHenan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is still one of the leading causes of cancer-associated death in the modern society. The biological function of miR-202-5p for CRC development remains controversial, largely due to the fact that miR-202-5p can be tumor-suppressive or oncogenic in different contexts. Obtained results indicated that aberrant expression of miR-202-5p was observed in majority of human CRC samples and miR-202-5p was transcriptionally up-regulated by c-Myc. In addition, miR-202-5p functions to promote the activation of PI3K/Akt signaling pathway by directly suppressing PTEN. Silencing or enforced expression of miR-202-5p resulted in CRC cell proliferation inhibition and enhancement, respectively. Importantly, decreased PTEN level and increased phosphorylation of Akt were frequently associated with elevated miR-202-5p expression in colorectal cancer tissues. Increased miR-202-5p expression may serve as a tumor promoter by directly targeting PTEN in colorectal cancer.

Indexed as

c-MycCRCmiR-202-5pPTEN

Identifiers

PMID33976725
PMCPMC8100819
OpenAlexW3155490852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.