Evidence map›Paper›PMID 33976708›Full record

ArticleCardiovascular therapeutics2021

Lipid Profile and Vascular Remodelling in Young Dyslipidemic Subjects Treated with Nutraceuticals Derived from Red Yeast Rice.

Massimo Puato, Alberto Zambon, Chiara Nardin, Elisabetta Faggin, Raffaele Pesavento, Alice Spinazzè, Paolo Pauletto, Marcello Rattazzi

Open access · goldAbstract read
In one paragraph

Article in Cardiovascular therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Massimo PuatoMedicina, Ospedale di Mirano, Mirano, Italy.ORCID https://orcid.org/0000-0001-6589-4824
Alberto ZambonDepartment of Medicine (DIMED), University of Padova, Italy.ORCID https://orcid.org/0000-0001-7096-5201
Chiara NardinDepartment of Medicine (DIMED), University of Padova, Italy.
Elisabetta FagginDepartment of Medicine (DIMED), University of Padova, Italy.
Raffaele PesaventoDepartment of Medicine (DIMED), University of Padova, Italy.ORCID https://orcid.org/0000-0001-9578-3455
Alice SpinazzèDepartment of Medicine (DIMED), University of Padova, Italy.
Paolo PaulettoORAS Rehabilitation Hospital, Motta di Livenza, Treviso, Italy.
Marcello RattazziDepartment of Medicine (DIMED), University of Padova, Italy.ORCID https://orcid.org/0000-0003-3437-7263
University of Padua · ITCa' Foncello Hospital · ITOspedale di Mirano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsA relevant role is emerging for functional foods in cardiovascular prevention. The aim of this study was to assess the effect of a nutraceutical multitargeted approach on lipid profile and inflammatory markers along with vascular remodelling in a cohort of dyslipidemic subjects without history of cardiovascular (CV) disease. METHODS AND

resultsWe enrolled 25 subjects (mean age 48.2 years) with low to moderate CV risk profile and total cholesterol (TC) levels between 150 and 250 mg/dl. The patients were assigned to receive for one year a tablet/die of a nutraceutical combination containing red yeast rice (RYR) extract (Monacolin 3 mg/tablet) and coenzyme Q10 (30 mg/tablet). Treatment with the nutraceutical compounds led to a significant reduction of TC (from 227 to 201 mg/dl,

conclusionsA long-term treatment with a combination of RYR and coenzyme Q10 showed lipid-lowering activity along with a reduction of inflammatory mediators and an improvement of vascular properties in young subjects with a low-to-moderate CV risk profile.

Indexed as

Biological ProductsVascular RemodelingAdultCardiovascular DiseasesCarotid Intima-Media ThicknessC-Reactive ProteinDietary SupplementsDyslipidemiasFemaleHumansLipidsMaleMiddle AgedUbiquinoneBiological Productscoenzyme Q10C-Reactive ProteinLipidsred yeast riceUbiquinone

Identifiers

PMID33976708
PMCPMC8087481
OpenAlexW3158589742

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.