Evidence map›Paper›PMID 33976453›Full record

ArticleGhana medical journal2020

Presentation and outcome of COVID-19 in HIV patients with high viral loads and opportunistic infections: a case series.

Yasmine O Hardy, Divine A Amenuke, Kojo A Hutton-Mensah, David R Chadwick, Rita Larsen-Reindorf

Abstract readCase Reports
In one paragraph

Article in Ghana medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. HIV and COVID-19: review of clinical course and outcomes.HIV research & clinical practice · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yasmine O HardyDepartment of Medicine, Komfo Anokye Teaching Hospital/School of Medical Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.
Divine A AmenukeDepartment of Medicine, Komfo Anokye Teaching Hospital/School of Medical Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.
Kojo A Hutton-MensahDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
David R ChadwickDepartment of Infectious Diseases, South Tees Hospitals NHS Foundation Trust, Centre for Clinical Infections, Middlesbrough, United Kingdom.
Rita Larsen-ReindorfAshanti Regional Health Directorate, Ghana Health Service, Kumasi, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is especially severe in patients with underlying chronic conditions, with increased risk of mortality. There is concern that people living with HIV (PLWH), especially those with severe immunosuppression, and COVID-19 may have severe disease and a negative clinical outcome. Most studies on COVID-19 in PLWH are from Asia, Europe and America where population dynamics, antiretroviral treatment coverage and coexisting opportunistic infections may differ from that in sub-Saharan Africa. We report on the clinical profile and outcome of three cases of PLWH co-infected with SARS-CoV-2. They all presented with fever, cough and breathlessness and also had advanced HIV infection as evidenced by opportunistic infections, high HIV viral loads and low CD4 counts. The patients responded favourably to the standard of care and were discharged home. Our findings suggest that PLWH with advanced immunosuppression may not necessarily have an unfavourable disease course and outcome. However, case-controlled studies with a larger population size are needed to better understand the impact of COVID-19 in this patient population.

fundingNot declared.

Indexed as

HIVSARS-CoV-2AdultAfrica South of the SaharaCoinfectionCOVID-19FemaleHIV InfectionsHumansMaleMiddle AgedOpportunistic InfectionsViral Loadadvanced HIVclinical outcomeCOVID-19GhanaSARS-CoV-2

Identifiers

PMID33976453
PMCPMC8087369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.