Evidence map›Paper›PMID 33976395›Full record

ReviewNature reviews. Nephrology2021

Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative.

John R Prowle, Lui G Forni, Max Bell, Michelle S Chew, Mark Edwards, Morgan E Grams, Michael P W Grocott, Kathleen D Liu, David McIlroy, Patrick T Murray and 20 more

2 registry-linked trialsOpen access · hybridAbstract readConsensus StatementReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 155 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 9 pooled it
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06783842 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Perioperative Depression, an Observational Cohort Study

Typeobservational_patient_registrySponsorKarolinska InstitutetRan2025 to 2026Enrolled700,000ConditionsSurgery With General Anesthesia, Depression - Major Depressive Disorder
NCT06802224 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Norepinephrine vs Phenylephrine as the First-line Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-cardiac Surgery

TypeinterventionalSponsorUniversity of California, San FranciscoRan2025 to 2028Enrolled18,000ConditionsAnesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During SurgeryArmsNorepinephrine, Phenylephrine
3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 9 syntheses or guidelines pooled it, 251 citations in OpenAlex.

  1. Pooled it
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  3. Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
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  5. Guideline
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  10. Trial
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  14. Review
  15. Article
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  17. Targeting a Novel AREGCell proliferation · 2026
    Article
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 9 countries.

John R ProwleCritical Care and Perioperative Medicine Research Group, William Harvey Research Institute, Queen Mary University of London, London, UK. j.prowle@qmul.ac.uk.ORCID http://orcid.org/0000-0002-5002-2721
Lui G ForniIntensive Care Unit, Royal Surrey Hospital NHS Foundation Trust, Guildford, UK.ORCID http://orcid.org/0000-0002-0617-5309
Max BellDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7464-0324
Michelle S ChewDepartment of Anesthesia and Intensive Care, Biomedical and Clinical Sciences, Linköping University Hospital, Linköping, Sweden.ORCID http://orcid.org/0000-0003-2888-4111
Mark EdwardsAnaesthesia and Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Morgan E GramsDivision of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Michael P W GrocottIntegrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Kathleen D LiuDivisions of Nephrology and Critical Care, Departments of Medicine and Anesthesia, University of California San Francisco School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4891-8649
David McIlroyDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Patrick T MurraySchool of Medicine, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0001-8516-1839
Marlies OstermannDepartment of Intensive Care, Guy's & St Thomas' NHS Foundation Hospital, London, UK.ORCID http://orcid.org/0000-0001-9500-9080
Alexander ZarbockDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Sean M BagshawDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, Edmonton, AB, Canada.
Raquel BartzDivision of Critical Care Medicine, Department of Anesthesia, Duke University Medical Center, Durham, NC, USA.
Samira BellDivision of Population Health and Genomics, University of Dundee, Dundee, Scotland, UK.ORCID http://orcid.org/0000-0001-9100-1575
Azra BihoracPrecision and Intelligent Systems in Medicine (PrismaP), Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-5745-2863
Tong J GanDepartment of Anesthesiology, Stony Brook University Renaissance School of Medicine, Stony Brook, NY, USA.
Charles E HobsonThe PACES Center for Value in Healthcare, Framingham, MA, USA.
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-6996-0881
Jay L KoynerSection of Nephrology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Denny Z H LevettIntegrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Ravindra L MehtaDivision of Nephrology, Department of Medicine, University of California, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-0908-2968
Timothy E MillerDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
Michael G MythenUniversity College London Hospitals NIHR Biomedical Research Centre, London, UK.
Mitra K NadimDivision of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rupert M PearseCritical Care and Perioperative Medicine Research Group, William Harvey Research Institute, Queen Mary University of London, London, UK.
Thomas RimmeleDepartment of Anesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
Claudio RoncoDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, International Renal Research Institute of Vicenza, and Department of Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-6697-4065
Andrew D Shaw *Department of Anesthesiology and Pain Medicine, Alberta Health Services, Edmonton, AB, Canada.
John A Kellum *Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-1995-2653
Alberta Health Services · CAQueen Mary University of London · GBUniversity of Southampton · GBDuke Medical Center · USDuke University · USGuy's and St Thomas' NHS Foundation Trust · GBHospices Civils de Lyon · FRInnsbruck Medical University · ATInternational Renal Research Institute of Vicenza · ITJohns Hopkins University · USKarolinska Institutet · SELinköping University Hospital · SEStony Brook School · USUCL Biomedical Research Centre · GBUniversity College Dublin · IEUniversity Hospital Münster · DEUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of California San Diego · USUniversity of California, San Francisco · USUniversity of Chicago · US

Funding

Integrating data, algorithms and clinical reasoning for surgical risk assessmentR01GM110240 · NIGMS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2016 to 2025
$5.1M
NIGMS NIH HHS R01 GM110240
6 · The paper itself

Abstract

Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and death. Risk factors for PO-AKI include older age and comorbid diseases such as chronic kidney disease and diabetes mellitus. PO-AKI is best defined as AKI occurring within 7 days of an operative intervention using the Kidney Disease Improving Global Outcomes (KDIGO) definition of AKI; however, additional prognostic information may be gained from detailed clinical assessment and other diagnostic investigations in the form of a focused kidney health assessment (KHA). Prevention of PO-AKI is largely based on identification of high baseline risk, monitoring and reduction of nephrotoxic insults, whereas treatment involves the application of a bundle of interventions to avoid secondary kidney injury and mitigate the severity of AKI. As PO-AKI is strongly associated with long-term adverse outcomes, some form of follow-up KHA is essential; however, the form and location of this will be dictated by the nature and severity of the AKI. In this Consensus Statement, we provide graded recommendations for AKI after non-cardiac surgery and highlight priorities for future research.

Indexed as

Acute Kidney InjuryHumansKidneyPostoperative ComplicationsRisk Factors

Identifiers

PMID33976395
PMCPMC8367817
OpenAlexW3160962109

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.