ArticleCommunications biology2021
Associative learning and extinction of conditioned threat predictors across sensory modalities.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Trial
- Mapping Pain Memory Across Modalities: Distinct Spatial Representations of Recalled Visceral and Somatic Pain.European journal of pain (London, England) · 2026Article
- Neural correlates of appetitive extinction learning: an fMRI study with actively participating pigeons.Scientific reports · 2026Article
- Convergent validation of the Involuntary Autobiographical Memory Inventory across levels of analysis in a Polish sample.Scientific reports · 2026Article
- Aversive memory and extinction learning for noxious stimuli and aversive tastants in bumblebees.The Journal of experimental biology · 2026Article
- The "Are You OK?" Paradox: A Scoping Review of Nocebo and Negative Suggestion in Healthcare Communication.Dentistry journal · 2026Review
- Article
- Article
- Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear.Scientific reports · 2025Article
- Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease.Molecular psychiatry · 2024Article
- An externally validated resting-state brain connectivity signature of pain-related learning.Communications biology · 2024Article
- Sex differences in the reactivity of gastric myoelectrical activity and heart rate variability as putative psychophysiological markers in human pain research.Frontiers in neuroscience · 2024Article
- Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health.Journal of Crohn's & colitis · 2023Article
- Neural underpinnings of preferential pain learning and the modulatory role of fear.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Interoception in Fear Learning and Posttraumatic Stress Disorder.Focus (American Psychiatric Publishing) · 2023Article
- Nocebo effects in visceral pain: concept and design of the experimental randomized-controlled pain study 'NoVis'.Frontiers in psychiatry · 2023Article
- [From gut feeling to visceral pain : Effects of negative expectations in the context of the gut-brain axis].Schmerz (Berlin, Germany) · 2022Review
- The Good, the Bad, and the Ugly-Chances, Challenges, and Clinical Implications of Avoidance Research in Psychosomatic Medicine.Frontiers in psychiatry · 2022Review
- Positive Treatment Expectations Shape Perceived Medication Efficacy in a Translational Placebo Paradigm for the Gut-Brain Axis.Frontiers in psychiatry · 2022Article
- Circulating Pro-inflammatory Cytokines Do Not Explain Interindividual Variability in Visceral Sensitivity in Healthy Individuals.Frontiers in neuroscience · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation and persistence of negative pain-related expectations by classical conditioning remain incompletely understood. We elucidated behavioural and neural correlates involved in the acquisition and extinction of negative expectations towards different threats across sensory modalities. In two complementary functional magnetic resonance imaging studies in healthy humans, differential conditioning paradigms combined interoceptive visceral pain with somatic pain (study 1) and aversive tone (study 2) as exteroceptive threats. Conditioned responses to interoceptive threat predictors were enhanced in both studies, consistently involving the insula and cingulate cortex. Interoceptive threats had a greater impact on extinction efficacy, resulting in disruption of ongoing extinction (study 1), and selective resurgence of interoceptive CS-US associations after complete extinction (study 2). In the face of multiple threats, we preferentially learn, store, and remember interoceptive danger signals. As key mediators of nocebo effects, conditioned responses may be particularly relevant to clinical conditions involving disturbed interoception and chronic visceral pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.