ArticleCommunications biology2021
Inhibition of a nutritional endosymbiont by glyphosate abolishes mutualistic benefit on cuticle synthesis in Oryzaephilus surinamensis.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- A bacterial symbiont and a plant virus enhance insect fitness by inducing physical defenses against fungal parasites.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Experimental Sodalis infection eliminates ancient insect symbiont.Nature communications · 2026Article
- Gut microbiota-mediated nitrogen recycling in the white Grub Holotrichia longipennis: A model for microbiome-targeted pest control.World journal of microbiology & biotechnology · 2026Article
- Insect‒microbe symbiosis-based strategies offer a new avenue for the management of insect pests and their transmitted pathogens.Crop health · 2024Review
- Intracellular symbiont Symbiodolus is vertically transmitted and widespread across insect orders.The ISME journal · 2024Article
- Evolutionary history of tyrosine-supplementing endosymbionts in pollen-feeding beetles.The ISME journal · 2024Article
- Barley Yellow Dwarf Virus Influences Its Vector's Endosymbionts but Not Its Thermotolerance.Microorganisms · 2023Article
- Cuticle supplementation and nitrogen recycling by a dual bacterial symbiosis in a family of xylophagous beetles.The ISME journal · 2023Article
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- Beetle elytra: evolution, modifications and biological functions.Biology letters · 2023Review
- Endosymbiosis allowsFrontiers in microbiology · 2023Article
- Rational engineering of a synthetic insect-bacterial mutualism.Current biology : CB · 2022Article
- Convergent evolution of a labile nutritional symbiosis in ants.The ISME journal · 2022Article
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- Host's demand for essential amino acids is compensated by an extracellular bacterial symbiont in a hemipteran insect model.Frontiers in physiology · 2022Article
- Nutritional symbionts enhance structural defence against predation and fungal infection in a grain pest beetle.The Journal of experimental biology · 2022Article
- Inhibition of a nutritional endosymbiont by glyphosate abolishes mutualistic benefit on cuticle synthesis in Oryzaephilus surinamensis.Communications biology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glyphosate is widely used as a herbicide, but recent studies begin to reveal its detrimental side effects on animals by targeting the shikimate pathway of associated gut microorganisms. However, its impact on nutritional endosymbionts in insects remains poorly understood. Here, we sequenced the tiny, shikimate pathway encoding symbiont genome of the sawtoothed grain beetle Oryzaephilus surinamensis. Decreased titers of the aromatic amino acid tyrosine in symbiont-depleted beetles underscore the symbionts' ability to synthesize prephenate as the precursor for host tyrosine synthesis and its importance for cuticle sclerotization and melanization. Glyphosate exposure inhibited symbiont establishment during host development and abolished the mutualistic benefit on cuticle synthesis in adults, which could be partially rescued by dietary tyrosine supplementation. Furthermore, phylogenetic analyses indicate that the shikimate pathways of many nutritional endosymbionts likewise contain a glyphosate sensitive 5-enolpyruvylshikimate-3-phosphate synthase. These findings highlight the importance of symbiont-mediated tyrosine supplementation for cuticle biosynthesis in insects, but also paint an alarming scenario regarding the use of glyphosate in light of recent declines in insect populations.
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