ArticleCommunications biology2021
Sequential production of gametes during meiosis in trypanosomes.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Experimental genetic crosses in tsetse flies of the livestock pathogen Trypanosoma congolense savannah.Parasites & vectors · 2024Article
- HOP1 and HAP2 are conserved components of the meiosis-related machinery required for successful mating in Leishmania.Nature communications · 2023Article
- Mitochondrial genome maintenance-the kinetoplast story.FEMS microbiology reviews · 2023Review
- Differential expression of meiosis and homologous recombination-related genes in the life cycle of Trypanosoma cruzi.Parasitology research · 2023Article
- Development of the livestock pathogen Trypanosoma (Nannomonas) simiae in the tsetse fly with description of putative sexual stages from the proboscis.Parasites & vectors · 2023Article
- Genome diversity ofFrontiers in cellular and infection microbiology · 2023Article
- Diagnosis of animal trypanosomoses: proper use of current tools and future prospects.Parasites & vectors · 2022Review
- Experimental Hybridization inPathogens (Basel, Switzerland) · 2022Review
- The genomic basis of host and vector specificity in non-pathogenic trypanosomatids.Biology open · 2022Article
- Single-cell transcriptomics reveals expression profiles of Trypanosoma brucei sexual stages.PLoS pathogens · 2022Article
- Signatures of hybridization in Trypanosoma brucei.PLoS pathogens · 2022Article
- Axenic interspecies and intraclonal hybrid formation in Leishmania: Successful crossings between visceral and cutaneous strains.PLoS neglected tropical diseases · 2022Article
- Stress conditions promoteeLife · 2022Article
- Sex in protists: A new perspective on the reproduction mechanisms of trypanosomatids.Genetics and molecular biology · 2022Article
- Reproduction in Trypanosomatids: Past and Present.Biology · 2021Review
- Life cycle strategies in free-living unicellular eukaryotes: Diversity, evolution, and current molecular tools to unravel the private life of microorganisms.The Journal of eukaryotic microbiologyReview
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Meiosis is a core feature of eukaryotes that occurs in all major groups, including the early diverging excavates. In this group, meiosis and production of haploid gametes have been described in the pathogenic protist, Trypanosoma brucei, and mating occurs in the salivary glands of the insect vector, the tsetse fly. Here, we searched for intermediate meiotic stages among trypanosomes from tsetse salivary glands. Many different cell types were recovered, including trypanosomes in Meiosis I and gametes. Significantly, we found trypanosomes containing three nuclei with a 1:2:1 ratio of DNA contents. Some of these cells were undergoing cytokinesis, yielding a mononucleate gamete and a binucleate cell with a nuclear DNA content ratio of 1:2. This cell subsequently produced three more gametes in two further rounds of division. Expression of the cell fusion protein HAP2 (GCS1) was not confined to gametes, but also extended to meiotic intermediates. We propose a model whereby the two nuclei resulting from Meiosis I undergo asynchronous Meiosis II divisions with sequential production of haploid gametes.
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