Evidence map›Paper›PMID 33976317›Full record

ArticleScientific reports2021

Phytochemical and antioxidant analysis of medicinal and food plants towards bioactive food and pharmaceutical resources.

Manyou Yu, Irene Gouvinhas, João Rocha, Ana I R N A Barros

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
31.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 344 citations in OpenAlex.

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  15. Biopreservation ofFoods (Basel, Switzerland) · 2025
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  18. Targeted3 Biotech · 2025
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  19. Phytochemical Screening and Biological Activities ofMolecules (Basel, Switzerland) · 2025
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  20. Antiaging Effect of 2-Foods (Basel, Switzerland) · 2025
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Manyou YuCentre for the Research and Technology of Agro-Environmental and Biological Sciences, CITAB, University de Trás-os-Montes e Alto Douro, UTAD, 5000-801, Vila Real, Portugal. jiangymy518@163.com.
Irene GouvinhasCentre for the Research and Technology of Agro-Environmental and Biological Sciences, CITAB, University de Trás-os-Montes e Alto Douro, UTAD, 5000-801, Vila Real, Portugal.
João RochaChemistry Centre-Vila Real, CQ-VR, UTAD, 5000-801, Vila Real, Portugal.
Ana I R N A BarrosCentre for the Research and Technology of Agro-Environmental and Biological Sciences, CITAB, University de Trás-os-Montes e Alto Douro, UTAD, 5000-801, Vila Real, Portugal. abarros@utad.pt.
University of Trás-os-Montes and Alto Douro · PTAssociation for the Development of Douro Viticulture · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants with medicinal properties play an increasingly important role in food and pharmaceutical industries for their functions on disease prevention and treatment. This study characterizes the phenolic composition and antioxidant activity of seven medicinal and food plants, including the leaves of Salvia officinalis L., Rosmarinus officinalis L., Olea europaea L., and Punica granatum L., as well as the leaves and young stems of Ruta graveolens L., Mentha piperita L., and Petroselinum crispum, Mill., by using colorimetric, chromatographic, and spectrophotometric assays. Results revealed that the hydro-methanolic leaf extracts of P. granatum (pomegranate) displayed the highest content of total phenols (199.26 mg gallic acid per gram of plant dry weight), ortho-diphenols (391.76 mg gallic acid per gram of plant dry weight), and tannins (99.20 mg epicatechin per gram of plant dry weight), besides a higher content of flavonoids (24 mg catechin per gram of plant dry weight). The highest antioxidant capacity measured by ABTS, DPPH, and FRAP (2.14, 2.27, and 2.33 mM Trolox per gram of plant dry weight, respectively) methods was also obtained in pomegranate leaf extracts, being 4-200 times higher than the other species. Such potent antioxidant activity of pomegranate leaves can be ascribed to the presence of different types of phenolic compounds and the high content in tannins, whilst phenolic acids and flavonoids were found to be the dominant phenolic classes of the other six plants. Consequently, despite the well-known antioxidant properties of these plant species, our study suggests pomegranate leaf can stand out as a relatively more valuable plant source of natural bioactive molecules for developing novel functional food-pharma ingredients, with potential for not only promoting human health but also improving bio-valorization and environment.

Indexed as

AntioxidantsCrops, AgriculturalFood AnalysisLamiaceaeOleaPetroselinumPhenolsPhytochemicalsPlant LeavesPlants, MedicinalPomegranateRutaAntioxidantsPhenolsPhytochemicals

Identifiers

PMID33976317
PMCPMC8113553
OpenAlexW3160355218

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.