Evidence map›Paper›PMID 33976287›Full record

Trial reportScientific reports2021

Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease.

Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani, Salman Yousif Alali, Alaa Mahmood Al Zamrooni, Amal Hamza Hejab, Ronán M Conroy, Pearl Wasif, Sameer Otoom, Stephen L Atkin and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04356534 (Use of Convalescent Plasma Therapy for COVID-19 Patients With Hypoxia), which is not on this map. Cited by 72 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 25 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04356534 nacompletednot on this map

Use of Convalescent Plasma Therapy for COVID-19 Patients With Hypoxia: a Prospective Randomized Trial

TypeinterventionalSponsorRoyal College of Surgeons in Ireland - Medical University of BahrainRan2020 to 2020Enrolled40ConditionsSARS-CoV 2, COVID-19Armsplasma therapy using convalescent plasma with antibody against SARS-CoV-2, Routine care for COVID-19 patients
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 25 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  3. Convalescent plasma for people with COVID-19: a living systematic review.The Cochrane database of systematic reviews · 2023
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  6. Convalescent plasma for people with COVID-19: a living systematic review.The Cochrane database of systematic reviews · 2023
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  7. Guideline
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  9. Lessons learned from the use of convalescent plasma for the treatment of COVID-19 and specific considerations for immunocompromised patients.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Manaf AlQahtaniBahrain Defence Force Hospital, Riffa, Bahrain. mqahtani@rcsi-mub.com.
Abdulkarim AbdulrahmanMohammed Bin Khalifa Cardiac Centre, Awali, Bahrain.
Abdulrahman AlmadaniBahrain Defence Force Hospital, Riffa, Bahrain.
Salman Yousif AlaliBahrain Defence Force Hospital, Riffa, Bahrain.
Alaa Mahmood Al ZamrooniSalmaniya Medical Complex, Manama, Bahrain.
Amal Hamza HejabBahrain Specialist Hospital, Manama, Bahrain.
Ronán M ConroyRoyal College of Surgeons in Ireland, Dublin, Ireland.
Pearl WasifRoyal College of Surgeons in Ireland-Bahrain, Busaiteen, Bahrain.
Sameer OtoomRoyal College of Surgeons in Ireland-Bahrain, Busaiteen, Bahrain.
Stephen L AtkinRoyal College of Surgeons in Ireland-Bahrain, Busaiteen, Bahrain.
Manal AbduljalilBahrain Defence Force Hospital, Riffa, Bahrain.
Royal College of Surgeons in Ireland - Bahrain · BHInternational Hospital of Bahrain · BHRoyal College of Surgeons in Ireland · IESalmaniya Medical Complex · BH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters and mortality at 28 days. The CP group were a higher risk group with higher ferritin levels (p < 0.05) though respiratory indices did not differ. The primary outcome measure was required in 6 controls and 4 patients on CP (risk ratio 0.67, 95% CI 0.22-2.0, p = 0.72); mean time on ventilation (NIV or MV) did not differ. There were no differences in secondary measures at the end of the study. Two patients died in the control and one patient in the CP arm. There were no significant differences in the primary or secondary outcome measures between CP and standard therapy, although a larger definitive study is needed for confirmation. However, the study did show that CP therapy appears to be safe in hospitalized COVID-19 patients with hypoxia.Clinical trials registration NCT04356534: 22/04/2020.

Indexed as

AdultAgedCOVID-19COVID-19 SerotherapyFemaleFerritinsHumansImmunization, PassiveMaleMiddle AgedPilot ProjectsProspective StudiesRespiration, ArtificialSARS-CoV-2Severity of Illness IndexSurvival RateFerritins

Identifiers

PMID33976287
PMCPMC8113529
OpenAlexW3160480118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.