Evidence map›Paper›PMID 33976269›Full record

ArticleScientific reports2021

Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India.

Sabyasachi Das, Amrita Kar, Subhankar Manna, Samaresh Mandal, Sayantani Mandal, Subhasis Das, Bhaskar Saha, Amiya Kumar Hati

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Spatiotemporal Epidemiology of Malaria in India from 2007 to 2022.The American journal of tropical medicine and hygiene · 2024
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  18. Genomic characterization ofFrontiers in cellular and infection microbiology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Sabyasachi DasDepartment of Physiology, Faculty of Medicine, Manipal University College Malaysia, Jalan Batu Hampar, Bukit Baru, 75150, Melaka, Malaysia. Sabyasachi.das@manipal.edu.my.
Amrita KarDepartment of Biotechnology, Centre for Research in Infectious Diseases, School of Chemical and Biotechnology, Sastra University, Thanjavur, Tamil Nadu, India.
Subhankar MannaDepartment of Human Physiology, Vidyasagar University, Midnapore, West Bengal, India.
Samaresh MandalDepartment of Human Physiology, Vidyasagar University, Midnapore, West Bengal, India.
Sayantani MandalMedicare, Bhilai, Chhattisgarh, India.
Subhasis DasMedicare, Bhilai, Chhattisgarh, India.
Bhaskar SahaLab 5, National Centre for Cell Science, Ganeshkhind, Pune, India.
Amiya Kumar HatiDepartment of Medical Entomology and Parasitology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
Vidyasagar University · INIndian Institute of Technology Bhilai · INManipal University College Malaysia · MYMedical College and Hospital, Kolkata · INNational Centre for Cell Science · INSASTRA University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artemisinin is the frontline fast-acting anti-malarial against P. falciparum. Emergence and spread of resistant parasite in eastern-India poses a threat to national malaria control programs. Therefore, the objective of our study is to evaluate the artesunate-sulfadoxine-pyrimethamine efficacy in Central India. 180 monoclonal P. falciparum-infected patients received standard ASSP therapy during August 2015-January 2017, soon after diagnosis and monitored over next 42-days. Artemisinin-resistance was assessed through in-vivo parasite clearance half-life (PC

Indexed as

AdolescentAdultAntimalarialsArtemisininsDrug ResistanceDrug Therapy, CombinationFemaleHumansIndiaKelch RepeatMalariaMalaria, FalciparumMaleMiddle AgedMutationPhenotypeAntimalarialsartemisininArtemisininsProtozoan ProteinsPyrimethamineSulfadoxineTetrahydrofolate Dehydrogenase

Identifiers

PMID33976269
PMCPMC8113598
OpenAlexW3163682116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.