ArticleNature communications2021
Molecular evolution and the decline of purifying selection with age.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels.Genome biology and evolution · 2025Article
- High Gene Expression Predicts Extremely Low Segregation of Deleterious Mutations in Large Penguin Populations.Molecular biology and evolution · 2025Article
- Decoding thymic development: a single-cell atlas of tree shrew immunity.Frontiers in immunology · 2025Article
- Exploring selection signatures in the divergence and evolution of lipid droplet (LD) associated genes in major oilseed crops.BMC genomics · 2024Article
- Senescence evolution under the catastrophic accumulation of deleterious mutations.Evolution letters · 2024Article
- More evidence for widespread antagonistic pleiotropy in polymorphic disease alleles.Frontiers in genetics · 2024Review
- Putative protective genomic variation in the Lithuanian population.Genetics and molecular biology · 2024Article
- Impacts of Natural Selection on Evolution of Core and Symbiotically Specialized (International journal of molecular sciences · 2023Article
- The evolution of aging and lifespan.Trends in genetics : TIG · 2023Review
- Integrating massive RNA-seq data to elucidate transcriptome dynamics in Drosophila melanogaster.Briefings in bioinformatics · 2023Article
- Transcriptional and mutational signatures of the Drosophila ageing germline.Nature ecology & evolution · 2023Article
- Ageing leads to reduced specificity of antimicrobial peptide responses inProceedings. Biological sciences · 2022Article
- Evolution and function of developmentally dynamic pseudogenes in mammals.Genome biology · 2022Article
- Tissue-specific impacts of aging and genetics on gene expression patterns in humans.Nature communications · 2022Article
- VectorBase.org updates: bioinformatic resources for invertebrate vectors of human pathogens and related organisms.Current opinion in insect science · 2022Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Life history theory predicts that the intensity of selection declines with age, and this trend should impact how genes expressed at different ages evolve. Here we find consistent relationships between a gene's age of expression and patterns of molecular evolution in two mammals (the human Homo sapiens and the mouse Mus musculus) and two insects (the malaria mosquito Anopheles gambiae and the fruit fly Drosophila melanogaster). When expressed later in life, genes fix nonsynonymous mutations more frequently, are more polymorphic for nonsynonymous mutations, and have shorter evolutionary lifespans, relative to those expressed early. The latter pattern is explained by a simple evolutionary model. Further, early-expressed genes tend to be enriched in similar gene ontology terms across species, while late-expressed genes show no such consistency. In humans, late-expressed genes are more likely to be linked to cancer and to segregate for dominant disease-causing mutations. Last, the effective strength of selection (N
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