ArticleNature communications2021
A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Advances in Adipose Tissue Biology.Endocrine reviews · 2026Review
- Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.The Journal of biological chemistry · 2025Review
- Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting.Scientific reports · 2025Article
- A comprehensive review of recent advances in the extraction and therapeutic potential of berberine.RSC advances · 2025Review
- AgRP neuron hyperactivity drives hyperglycemia in a mouse model of type 2 diabetes.The Journal of clinical investigation · 2025Article
- GABAMedComm · 2025Review
- Targeting GABA signaling in type 1 diabetes and its complications- an update on the state of the art.Pharmacological reports : PR · 2025Review
- Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes.Communications biology · 2025Article
- The stress hyperglycemia ratio as a predictor of short- and long-term mortality in patients with acute brain injury: a retrospective cohort study.Frontiers in neurology · 2025Article
- Multi-omics investigation of prospective therapeutic targets for type 1 diabetes.Therapeutic advances in endocrinology and metabolism · 2025Article
- Assessment of ImmobilizedFoods (Basel, Switzerland) · 2024Article
- Methodology for Studying Hypothalamic Regulation of Feeding Behaviors.Methods and protocols · 2024Review
- S100A9 exerts insulin-independent antidiabetic and anti-inflammatory effects.Science advances · 2024Article
- Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis.Journal of diabetes investigation · 2023Article
- Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation on Adiposity and mRNA Expression of Energy Balance Related Genes in Obese Male Rats.Metabolites · 2023Article
- Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies.International journal of molecular sciences · 2023Review
- Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin.Diabetes · 2022Article
- Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis.Nature communications · 2022Article
- The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis.Cell & bioscience · 2022Review
- Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior.Biomolecules · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Shengjie Fan *School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuanzhong Xu *Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-5264-5324
Yungang LuBrown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-8949-661X
Zhiying JiangBrown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Hongli LiBrown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jessie C MorrillBrown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jing CaiBrown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Qi WuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID 0000-0003-0303-4065
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID 0000-0002-4908-1572
Mingshan XueDepartment of Neuroscience and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-1463-8884
Benjamin R ArenkielDepartment of Molecular and Human Genetics and Department of Neuroscience, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0001-9047-2420
Cheng HuangSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China. chuang@shutcm.edu.cn.
Qingchun TongBrown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Qingchun.tong@uth.tmc.edu.ORCID 0000-0002-4561-2540
Brown Foundation · USBaylor College of Medicine · USShanghai University of Traditional Chinese Medicine · CNChildren's Nutrition Research Center at Baylor College of Medicine · USThe University of Texas MD Anderson Cancer Center · US
Funding
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MR01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4MActivity-Dependent Mechanisms Regulating Synaptic Excitation and Inhibition in Neural CircuitsR01MH117089 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI XUE, MINGSHAN · 2018 to 2022
$2.0M5-HT NEURONS INTEGRATE NEURAL INPUTS TO REGULATE FOOD INTAKER01DK120858 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TONG, QINGCHUN, XU, YONG · 2020 to 2023
$1.9MNeurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8MA Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR01DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2017 to 2021
$1.8MA direct LH to PVH projection for antagonistic regulation of feedingR01DK114279 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2018 to 2021
$1.5MTargeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2MTo explore the mechanism underlying developmental compensations in PVH neuronsR21NS108091 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2019 to 2019
$426kNICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01 DK109194NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R01 DK120858NIMH NIH HHS R01 MH117089NINDS NIH HHS R21 NS108091
Abstract
Central leptin action rescues type 1 diabetic (T1D) hyperglycemia; however, the underlying mechanism and the identity of mediating neurons remain elusive. Here, we show that leptin receptor (LepR)-expressing neurons in arcuate (LepR
Indexed as
Agouti-Related ProteinAMP-Activated Protein KinasesAnimalsBlood GlucoseBrainDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1GABAergic NeuronsHyperglycemiaInfusions, IntraventricularLeptinMaleMice, TransgenicNeuronsReceptors, LeptinSignal TransductionAgouti-Related ProteinAgrp protein, mouseAMP-Activated Protein KinasesBlood GlucoseLeptinReceptors, Leptin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.