ArticleNature communications2021
Sugar transporters enable a leaf beetle to accumulate plant defense compounds.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Development of venus-fused Cypridina luciferase (VCL) and specific nanobody-tethering assay to model kleptoprotein uptake.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Regionality and Temporal Dynamics of Sequestration and Relocation of Cardenolides in the Monarch Butterfly, Danaus plexippus.Journal of chemical ecology · 2025Article
- Evaluating the Effects of Flavonoids on Insects: Implications for Managing Pests Without Harming Beneficials.Insects · 2024Review
- Genome-Wide Identification and Expression Pattern of Sugar Transporter Genes in the Brown Planthopper,Insects · 2024Article
- Metabolism of plant-derived toxins from its insect host increases the success of the entomopathogenic fungus Beauveria bassiana.The ISME journal · 2023Article
- Expression Analysis Reveals Differentially Expressed Genes in BPH and WBPH Associated with Resistance in Rice RILs Derived from a Cross between RP2068 and TN1.International journal of molecular sciences · 2023Article
- No-cost meals might not exist for insects feeding on toxic plants.Biology open · 2023Review
- Artificial Fluorescent Glucosinolates (F-GSLs) Are Transported by the Glucosinolate Transporters GTR1/2/3.International journal of molecular sciences · 2023Article
- Specialist root herbivore modulates plant transcriptome and downregulates defensive secondary metabolites in a brassicaceous plant.The New phytologist · 2022Article
- Unique metabolism of different glucosinolates in larvae and adults of a leaf beetle specialised on Brassicaceae.Scientific reports · 2022Article
- Gene expression profiles in Malpighian tubules of the vector leafhopper Psammotettix striatus (L.) revealed regional functional diversity and heterogeneity.BMC genomics · 2022Article
- An inducible gene from glycoside hydrolase one family ofFrontiers in physiology · 2022Article
- Rapid and Selective Absorption of Plant Defense Compounds From the Gut of a Sequestering Insect.Frontiers in physiology · 2022Article
- Metabolization and sequestration of plant specialized metabolites in insect herbivores: Current and emerging approaches.Frontiers in physiology · 2022Review
- Edible Aquatic Insects: Diversities, Nutrition, and Safety.Foods (Basel, Switzerland) · 2021Review
- Hijacking the Mustard-Oil Bomb: How a Glucosinolate-Sequestering Flea Beetle Copes With Plant Myrosinases.Frontiers in plant science · 2021Article
- The Cell Differentiation of Idioblast Myrosin Cells: Similarities With Vascular and Guard Cells.Frontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many herbivorous insects selectively accumulate plant toxins for defense against predators; however, little is known about the transport processes that enable insects to absorb and store defense compounds in the body. Here, we investigate how a specialist herbivore, the horseradish flea beetle, accumulates glucosinolate defense compounds from Brassicaceae in the hemolymph. Using phylogenetic analyses of coleopteran major facilitator superfamily transporters, we identify a clade of glucosinolate-specific transporters (PaGTRs) belonging to the sugar porter family. PaGTRs are predominantly expressed in the excretory system, the Malpighian tubules. Silencing of PaGTRs leads to elevated glucosinolate excretion, significantly reducing the levels of sequestered glucosinolates in beetles. This suggests that PaGTRs reabsorb glucosinolates from the Malpighian tubule lumen to prevent their loss by excretion. Ramsay assays corroborated the selective retention of glucosinolates by Malpighian tubules of P. armoraciae in situ. Thus, the selective accumulation of plant defense compounds in herbivorous insects can depend on the ability to prevent excretion.
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