Evidence map›Paper›PMID 33976193›Full record

ArticleNature communications2021

Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice.

Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai, Qinghua Liu

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Can LiuPeking University-Tsinghua University-NIBS Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0001-5772-7989
Chia-Ying LeeInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Greg AsherInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Liqin CaoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Yuka TerakoshiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Peng CaoNational Institute of Biological Sciences (NIBS), Beijing, China.ORCID http://orcid.org/0000-0001-7739-6857
Reiko KobayakawaDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University, Osaka, Japan.ORCID http://orcid.org/0000-0001-6613-5969
Ko KobayakawaDepartment of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University, Osaka, Japan.ORCID http://orcid.org/0000-0001-6406-5610
Katsuyasu SakuraiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan. sakurai.katsuyasu.gm@u.tsukuba.ac.jp.
Qinghua LiuNational Institute of Biological Sciences (NIBS), Beijing, China. liuqinghua@nibs.ac.cn.ORCID http://orcid.org/0000-0002-5996-0634
University of Tsukuba · JPKansai Medical University · JPNational Institute of Biological Sciences, Beijing · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative of vasodilation-induced heat dissipation, in wild-type mice, but not in mice lacking Trpa1-the chemosensor for 2MT. Here we report that Trpa1

Indexed as

AnimalsBody Temperature RegulationFearHypothermiaMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsOptogeneticsProto-Oncogene Proteins c-fosSolitary NucleusSubthalamic NucleusThiazolesTRPA1 Cation ChannelVasodilation2-methylthiazolineProto-Oncogene Proteins c-fosThiazolesTRPA1 Cation ChannelTrpa1 protein, mouse

Identifiers

PMID33976193
PMCPMC8113537
OpenAlexW3114349421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.